Qualitative and quantitative HIV antibodies and viral reservoir size characterization in vertically infected children with virological suppression

Josephine Brice*, Mariam Sylla, Sophie Sayon, Fatoumata Telly, Djeneba Bocar-Fofana, Robert Murphy, Sidonie Lambert-Niclot, Eve Todesco, Maxime Grude, Francis Barin, Souleymane Diallo, Deenan Pillay, Anne Derache, Vincent Calvez, Anne Geneviève Marcelin, Almoustapha Issiaka Maiga

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Background: Absence of detectable viraemia after treatment cessation in some vertically HIV-infected (VHIV) children suggests that early initiation of HAART could lead to functional cure. Objectives: We described the factors associated with HIV antibody levels and the viral reservoir size in HAART-treated VHIV children. Methods: Study included 97 VHIV children with virological suppression, in Bamako, Mali. The anti-gp41 antibody activities and HIV serostatus were assessed. The viral reservoir size was measured by quantifying total cellassociated HIV DNA. Results: Among the children studied, the median total HIV DNA level was 445 copies/106 cells (IQR=187-914) and the median anti-gp41 antibody activity was 0.29 OD (IQR=0.18-0.75). Low activity of anti-gp41 antibodies was associated with a younger age of HAART initiation (P=0.01). Overall, eight HIV-1 seroreversions were identified. Conclusions: Study identified potential candidates with low viral reservoir and low antibody levels or activities for future trials aiming to reduce HIV-1 reservoir to limit HAART duration.

Original languageEnglish (US)
Pages (from-to)1147-1151
Number of pages5
JournalJournal of Antimicrobial Chemotherapy
Volume72
Issue number4
DOIs
StatePublished - 2017

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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    Brice, J., Sylla, M., Sayon, S., Telly, F., Bocar-Fofana, D., Murphy, R., Lambert-Niclot, S., Todesco, E., Grude, M., Barin, F., Diallo, S., Pillay, D., Derache, A., Calvez, V., Marcelin, A. G., & Maiga, A. I. (2017). Qualitative and quantitative HIV antibodies and viral reservoir size characterization in vertically infected children with virological suppression. Journal of Antimicrobial Chemotherapy, 72(4), 1147-1151. https://doi.org/10.1093/jac/dkw537