Quality of life associated with daily opioid therapy in a primary care chronic pain sample

Kathryn Sullivan Dillie, Michael F. Fleming, Marlon P. Mundt, Michael T. French

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


Background: Daily opioid therapy is widely used in the treatment of chronic noncancer pain, yet there is limited empirical evidence on the relationship of opioid dosing and health-related quality of life (HRQoL) in primary care settings. Methods: An analysis was conducted to assess the relationship of opioid dose to quality of life. The sample consisted of 801 chronic pain patients who were prescribed daily opioids and 93 non-opioid users recruited from the practices of 235 primary care physicians. Eight HRQoL domain scores were calculated and compared with US norms and across opioid use groups. A new modeling technique, propensity score matching analysis, was performed to adjust for potential confounding factors across 4 morphine-equivalent opioid dose groups (<20 mg, 20-40 mg, 41-105 mg, >105 mg). Results: HRQoL scores were significantly lower in chronic noncancer pain patients relative to the US general population regardless of opioid use. In unadjusted comparisons, those using up to 20 mg/d of opioids had the highest HRQoL scores, whereas those using >105 mg/d had the lowest. After adjusting for potential confounders, those in the 20 mg to 40 mg/d dosing group had significantly better HRQoL scores than their non opioid-treated or higher dosed counterparts. Conclusion: Use of low- to moderate-dose opioid therapy provides an improvement in HRQoL scores for chronic noncancer pain patients compared to no opioid therapy, while high-dose opioids have a smaller positive effect that is limited to mental health quality of life and patient satisfaction, and that may not justify treatment.

Original languageEnglish (US)
Pages (from-to)108-117
Number of pages10
JournalJournal of the American Board of Family Medicine
Issue number2
StatePublished - Mar 2008

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Family Practice


Dive into the research topics of 'Quality of life associated with daily opioid therapy in a primary care chronic pain sample'. Together they form a unique fingerprint.

Cite this