Quality of Life in Adult Survivors Greater Than 10 Years After Pediatric Heart Transplantation

Rebecca A. Petroski, Kathleen L Grady, Sherrie Rodgers, Carl L Backer, Agnieszka Kulikowska, Charles Canter, Elfriede Pahl*

*Corresponding author for this work

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: This study assessed quality of life (QOL) in adult survivors of pediatric heart transplantation who survived ≥ 10 years after transplantation. Methods: Prospective data were collected from heart transplant recipients who were aged ≥ 18 years and had survived ≥ 10 years after transplantation (transplantation between July 3, 1986, and April 4, 1997). QOL data were collected from patients using the Medical Outcomes Study 36-Item Short Form (SF-36) Health Survey. Clinical data were collected from medical records. Statistical analyses included frequencies and measures of central tendency. Results: Twenty-three patients (65% men, 91% white) completed the study. At the study initiation, they were a mean age of 9.0 ± 7.1 years at transplantation, and were a mean age of 25.2 ± 5.5 years (range, 18-34 years) and a mean of 16.2 ± 3.0 years (range, 11-22 years) post-transplantation. Most were in school or working. Mean patient QOL scores from the SF-36v2 survey were 50.56 ± 0.5 (range, 27.3-68.9) for physical health and 49.88 ± 11.72 (range, 23.56-62.84) for mental health, similar to the general United States population. Late complications were frequent, including transplant coronary artery disease, 3; repeat heart transplantation, 2; post-transplantation lymphoproliferative disorder, 6; kidney transplantation, 5; acute late rejection, 5; and arrhythmias, 4. Conclusion: This report of QOL in adult survivors of pediatric heart transplantation shows patient perception of physical and mental health is similar to the general population despite serious late complications. A multicenter study is planned to further evaluate QOL in this unique cohort.

Original languageEnglish (US)
Pages (from-to)661-666
Number of pages6
JournalJournal of Heart and Lung Transplantation
Volume28
Issue number7
DOIs
StatePublished - Jul 1 2009

Fingerprint

Heart Transplantation
Survivors
Transplantation
Quality of Life
Pediatrics
Mental Health
Lymphoproliferative Disorders
Health Surveys
Kidney Transplantation
Population
Multicenter Studies
Medical Records
Cardiac Arrhythmias
Coronary Artery Disease
Outcome Assessment (Health Care)
Transplants
Health

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

Cite this

Petroski, Rebecca A. ; Grady, Kathleen L ; Rodgers, Sherrie ; Backer, Carl L ; Kulikowska, Agnieszka ; Canter, Charles ; Pahl, Elfriede. / Quality of Life in Adult Survivors Greater Than 10 Years After Pediatric Heart Transplantation. In: Journal of Heart and Lung Transplantation. 2009 ; Vol. 28, No. 7. pp. 661-666.
@article{0e579e09eac34bbfa4ddea78f8c88872,
title = "Quality of Life in Adult Survivors Greater Than 10 Years After Pediatric Heart Transplantation",
abstract = "Background: This study assessed quality of life (QOL) in adult survivors of pediatric heart transplantation who survived ≥ 10 years after transplantation. Methods: Prospective data were collected from heart transplant recipients who were aged ≥ 18 years and had survived ≥ 10 years after transplantation (transplantation between July 3, 1986, and April 4, 1997). QOL data were collected from patients using the Medical Outcomes Study 36-Item Short Form (SF-36) Health Survey. Clinical data were collected from medical records. Statistical analyses included frequencies and measures of central tendency. Results: Twenty-three patients (65{\%} men, 91{\%} white) completed the study. At the study initiation, they were a mean age of 9.0 ± 7.1 years at transplantation, and were a mean age of 25.2 ± 5.5 years (range, 18-34 years) and a mean of 16.2 ± 3.0 years (range, 11-22 years) post-transplantation. Most were in school or working. Mean patient QOL scores from the SF-36v2 survey were 50.56 ± 0.5 (range, 27.3-68.9) for physical health and 49.88 ± 11.72 (range, 23.56-62.84) for mental health, similar to the general United States population. Late complications were frequent, including transplant coronary artery disease, 3; repeat heart transplantation, 2; post-transplantation lymphoproliferative disorder, 6; kidney transplantation, 5; acute late rejection, 5; and arrhythmias, 4. Conclusion: This report of QOL in adult survivors of pediatric heart transplantation shows patient perception of physical and mental health is similar to the general population despite serious late complications. A multicenter study is planned to further evaluate QOL in this unique cohort.",
author = "Petroski, {Rebecca A.} and Grady, {Kathleen L} and Sherrie Rodgers and Backer, {Carl L} and Agnieszka Kulikowska and Charles Canter and Elfriede Pahl",
year = "2009",
month = "7",
day = "1",
doi = "10.1016/j.healun.2009.04.004",
language = "English (US)",
volume = "28",
pages = "661--666",
journal = "Journal of Heart and Lung Transplantation",
issn = "1053-2498",
publisher = "Elsevier USA",
number = "7",

}

Quality of Life in Adult Survivors Greater Than 10 Years After Pediatric Heart Transplantation. / Petroski, Rebecca A.; Grady, Kathleen L; Rodgers, Sherrie; Backer, Carl L; Kulikowska, Agnieszka; Canter, Charles; Pahl, Elfriede.

In: Journal of Heart and Lung Transplantation, Vol. 28, No. 7, 01.07.2009, p. 661-666.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Quality of Life in Adult Survivors Greater Than 10 Years After Pediatric Heart Transplantation

AU - Petroski, Rebecca A.

AU - Grady, Kathleen L

AU - Rodgers, Sherrie

AU - Backer, Carl L

AU - Kulikowska, Agnieszka

AU - Canter, Charles

AU - Pahl, Elfriede

PY - 2009/7/1

Y1 - 2009/7/1

N2 - Background: This study assessed quality of life (QOL) in adult survivors of pediatric heart transplantation who survived ≥ 10 years after transplantation. Methods: Prospective data were collected from heart transplant recipients who were aged ≥ 18 years and had survived ≥ 10 years after transplantation (transplantation between July 3, 1986, and April 4, 1997). QOL data were collected from patients using the Medical Outcomes Study 36-Item Short Form (SF-36) Health Survey. Clinical data were collected from medical records. Statistical analyses included frequencies and measures of central tendency. Results: Twenty-three patients (65% men, 91% white) completed the study. At the study initiation, they were a mean age of 9.0 ± 7.1 years at transplantation, and were a mean age of 25.2 ± 5.5 years (range, 18-34 years) and a mean of 16.2 ± 3.0 years (range, 11-22 years) post-transplantation. Most were in school or working. Mean patient QOL scores from the SF-36v2 survey were 50.56 ± 0.5 (range, 27.3-68.9) for physical health and 49.88 ± 11.72 (range, 23.56-62.84) for mental health, similar to the general United States population. Late complications were frequent, including transplant coronary artery disease, 3; repeat heart transplantation, 2; post-transplantation lymphoproliferative disorder, 6; kidney transplantation, 5; acute late rejection, 5; and arrhythmias, 4. Conclusion: This report of QOL in adult survivors of pediatric heart transplantation shows patient perception of physical and mental health is similar to the general population despite serious late complications. A multicenter study is planned to further evaluate QOL in this unique cohort.

AB - Background: This study assessed quality of life (QOL) in adult survivors of pediatric heart transplantation who survived ≥ 10 years after transplantation. Methods: Prospective data were collected from heart transplant recipients who were aged ≥ 18 years and had survived ≥ 10 years after transplantation (transplantation between July 3, 1986, and April 4, 1997). QOL data were collected from patients using the Medical Outcomes Study 36-Item Short Form (SF-36) Health Survey. Clinical data were collected from medical records. Statistical analyses included frequencies and measures of central tendency. Results: Twenty-three patients (65% men, 91% white) completed the study. At the study initiation, they were a mean age of 9.0 ± 7.1 years at transplantation, and were a mean age of 25.2 ± 5.5 years (range, 18-34 years) and a mean of 16.2 ± 3.0 years (range, 11-22 years) post-transplantation. Most were in school or working. Mean patient QOL scores from the SF-36v2 survey were 50.56 ± 0.5 (range, 27.3-68.9) for physical health and 49.88 ± 11.72 (range, 23.56-62.84) for mental health, similar to the general United States population. Late complications were frequent, including transplant coronary artery disease, 3; repeat heart transplantation, 2; post-transplantation lymphoproliferative disorder, 6; kidney transplantation, 5; acute late rejection, 5; and arrhythmias, 4. Conclusion: This report of QOL in adult survivors of pediatric heart transplantation shows patient perception of physical and mental health is similar to the general population despite serious late complications. A multicenter study is planned to further evaluate QOL in this unique cohort.

UR - http://www.scopus.com/inward/record.url?scp=67649094103&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649094103&partnerID=8YFLogxK

U2 - 10.1016/j.healun.2009.04.004

DO - 10.1016/j.healun.2009.04.004

M3 - Article

C2 - 19560692

AN - SCOPUS:67649094103

VL - 28

SP - 661

EP - 666

JO - Journal of Heart and Lung Transplantation

JF - Journal of Heart and Lung Transplantation

SN - 1053-2498

IS - 7

ER -