Quality of life in multiple sclerosis patients in Spain

C. H. Chang*, D. Cella, O. Fernández, G. Luque, P. De Castro, C. De Andrés, B. Casanova, M. A. Hernández, J. M. Prieto, V. E. Fernández, E. De Ramón

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Objective: The cross-sectional study evaluated the psychometric properties of the Functional Assessment of Multiple Sclerosis (FAMS) Spanish version and its use in measuring quality of life (QOL) of multiple sclerosis (MS) patients in Spain. Methods: The FAMS is a factorially derived self-report scale designed to assess six primary aspects of QOL of patients with MS: Mobility, Symptoms, Emotional Well-Being, General Contentment, Thinking and Fatigue, and Family/Social Well-Being. Its Spanish translated version was used to assess QOL of 625 MS patients recruited in an outpatient clinic setting from 58 hospitals in Spain. Internal consistency of the Spanish FAMS was evaluated. Multiple regression analyses were performed to identify significant predictors from demographic, clinical and treatment characteristics, and Kurtzke Expanded Disability Status Scale (EDSS) scores in predicting FAMS scale scores. Results: Most of the patients are females (66%), and 74% were of the relapsing-remitting (RR) clinical subtype. Cronbach's alpha coefficients were high (range=0.78-0.96), indicating subscale homogeneity comparable to that of the original English version. Linear multivariate regression analyses revealed that the EDSS is a dominant variable in predicting all the FAMS subscales, especially mobility (R2=0.51) and the total scores. Conclusions: The Spanish FAMS is a psychometrically valid instrument that allows clinicians and clinical researchers the ability to measure the QOL concerns of MS patients in Spain.

Original languageEnglish (US)
Pages (from-to)527-531
Number of pages5
JournalMultiple Sclerosis
Issue number6
StatePublished - Dec 2002


  • EDSS
  • FAMS
  • Multiple sclerosis
  • Quality of life

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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