Quality of Life in Patients with Low-Grade Non-Hodgkin's Lymphoma

K. Webster, D. Cella*, K. Basen-Engquist, J. O. Armitage

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Low-grade non-Hodgkin's lymphoma (NHL) is an indolent form of the disease with a generally slow course of progression. Although still usually incurable, low-grade disease has shown responsiveness to some of the newer chemotherapeutic and nonchemotherapeutic treatment options. However, since cure remains elusive, and since many patients with low-grade NHL may have few or even no symptoms initially, the decision about whether or not to initiate treatment logically must include quality-of-life (QOL) issues. This paper summarizes clinical and diagnostic characteristics of low-grade NHL that have some bearing on QOL considerations. Adverse effects of the more common treatment approaches are discussed according to their QOL implications, illustrating the relevance of QOL to the clinical management of low-grade disease. Finally, data from an ongoing study using the Functional Assessment of Cancer Therapy (FACT) measurement system are presented. These data offer a basis for comparing the QOL of patients with NHL to that of individuals with other solid tumors, and also illustrate the effects of chemotherapy on QOL.

Original languageEnglish (US)
Pages (from-to)697-714
Number of pages18
Issue number5
StatePublished - 1998

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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