Quality of life measurement in bone marrow transplantation: Development of the functional assessment of cancer therapy-bone marrow transplant (FACT-BMT) scale

R. P. McQuellon*, G. B. Russell, D. F. Cella, B. L. Craven, M. Brady, A. Bonomi, D. D. Hurd

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

274 Scopus citations

Abstract

We developed a 12-item bone marrow transplant subscale (BMTS) for the general Functional Assessment of Cancer Therapy (FACT) measure. The subscale combined with the FACT, (FACT-BMT) is a 47-item, valid and reliable measure of five dimensions of quality of life in bone marrow transplant patients. The three-step validation process involved the generation and selection of BMT-specific items and the testing of the overall measure. Items were selected from a list produced by seven oncology experts and 15 patients and were designed to assess content not represented in the general FACT items. A total of 182 patients completed the FACT-BMT at baseline, prior to BMT. An analysis measuring sensitivity to change was performed with 74 patients after transplantation and 60 patients over the three time-points of baseline, hospital discharge and 100 days. The FACT-BMT and all subscales were correlated, sensitivity to change was measured, and the internal consistency for each scale was calculated. Coefficients of reliability and validity ranged from 0.86 to 0.89 for the entire PACT-BMT and 0.54 to 0.63 for the BMTS. The BMTS was able to discriminate patients on the basis of performance status rating and also demonstrated sensitivity to change over time. The FACT-BMT has good psychometric properties for use in assessing quality of life in bone marrow transplant patients. The addition of the bone marrow transplant subscale to the general FACT measure makes it an excellent choice for use in BMT clinical trials.

Original languageEnglish (US)
Pages (from-to)357-368
Number of pages12
JournalBone Marrow Transplantation
Volume19
Issue number4
DOIs
StatePublished - Feb 2 1997

Keywords

  • Functional assessment
  • Marrow transplantation
  • Quality of life

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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