Quality-of-life results of double-blind, placebo-controlled trial of mesalamine in patients with Crohn's disease

John W. Singleton*, Stephen Hanauer, Malcolm Robinson

*Corresponding author for this work

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Seven quality-of-life parameters were assessed in a trial of mesalamine in Crohn's disease. The results with regard to efficacy and safety have been previously published. A total of 310 patients were enrolled in this double-blind, parallel trial and randomized to receive placebo, or 1, 2, or 4 g/day of mesalamine in controlled-release capsules for 16 weeks. Results revealed that mesalamine at the dose of 4 g/day resulted in significant (P<0.03) improvements from baseline in all quality-of-life parameters. A significant (P<0.02) linear trend between increasing doses of mesalamine and increasing response was also noted. The 1- and 2-g/day doses of mesalamine also resulted in an improvement in quality of life, however, with the exception of 2 g/day of mesalamine on the hobby and recreational activities parameter, these changes were not significantly different from placebo.

Original languageEnglish (US)
Pages (from-to)931-935
Number of pages5
JournalDigestive diseases and sciences
Volume40
Issue number5
DOIs
StatePublished - May 1 1995

Keywords

  • Crohn's disease
  • mesalamine
  • quality of life

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Quality-of-life results of double-blind, placebo-controlled trial of mesalamine in patients with Crohn's disease'. Together they form a unique fingerprint.

  • Cite this