TY - JOUR
T1 - Quality of life with brain symptom and impact questionnaire in patients with brain metastases
AU - Chow, Ronald
AU - Ray, Saurabh
AU - Tsao, May
AU - Pulenzas, Natalie
AU - Zhang, Liying
AU - Sahgal, Arjun
AU - Cella, David
AU - Soliman, Hany
AU - Danjoux, Cyril
AU - DeAngelis, Carlo
AU - Vuong, Sherlyn
AU - McDonald, Rachel
AU - Chow, Edward
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Background: To examine the baseline characteristics of patients who underwent different treatments for brain metastases. Methods: Allocated into group A [whole brain radiation therapy (WBRT) alone], or group B [stereotactic radiosurgery (SRS) or neurosurgery with or without WBRT], brain metastases patients with assigned treatment completed the Brain Symptom and Impact Questionnaire (BASIQ). Items of BASIQ were arranged as a symptom score or function score. Results: Lung, breast, melanoma and renal cancer were the most prevalent primary cancer site among the study population, with 91 (53%), 25 (15%), 17 (10%) and 15 (9%) patients, respectively. Baseline BASIQ results were obtained before patients were treated with WBRT, neurosurgery, or SRS. Seventy-six (44%) and 96 patients (56%) were grouped to A and B, respectively. Group A reported lower quality of life (QOL) in all function scores (P<0.0001) and all symptom scores (P values from <0.0001 to 0.005) with the exception of energy (P=0.1). Conclusions: Baseline QOL in patients assigned WBRT alone was statistically worse as compared to patients assigned SRS, neurosurgery with or without WBRT.
AB - Background: To examine the baseline characteristics of patients who underwent different treatments for brain metastases. Methods: Allocated into group A [whole brain radiation therapy (WBRT) alone], or group B [stereotactic radiosurgery (SRS) or neurosurgery with or without WBRT], brain metastases patients with assigned treatment completed the Brain Symptom and Impact Questionnaire (BASIQ). Items of BASIQ were arranged as a symptom score or function score. Results: Lung, breast, melanoma and renal cancer were the most prevalent primary cancer site among the study population, with 91 (53%), 25 (15%), 17 (10%) and 15 (9%) patients, respectively. Baseline BASIQ results were obtained before patients were treated with WBRT, neurosurgery, or SRS. Seventy-six (44%) and 96 patients (56%) were grouped to A and B, respectively. Group A reported lower quality of life (QOL) in all function scores (P<0.0001) and all symptom scores (P values from <0.0001 to 0.005) with the exception of energy (P=0.1). Conclusions: Baseline QOL in patients assigned WBRT alone was statistically worse as compared to patients assigned SRS, neurosurgery with or without WBRT.
KW - Brain metastases
KW - Cancer
KW - Quality of life (QOL)
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UR - http://www.scopus.com/inward/citedby.url?scp=85001044619&partnerID=8YFLogxK
U2 - 10.21037/apm.2016.04.01
DO - 10.21037/apm.2016.04.01
M3 - Article
C2 - 27199270
AN - SCOPUS:85001044619
SN - 2224-5820
VL - 5
SP - 179
EP - 189
JO - Annals of Palliative Medicine
JF - Annals of Palliative Medicine
IS - 3
ER -
