Quantification of Absolute Myocardial Blood Flow by Magnetic Resonance Perfusion Imaging

Daniel C. Lee*, Nils P. Johnson

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

56 Scopus citations

Abstract

By serially imaging the myocardium during the initial transit of gadolinium contrast, magnetic resonance perfusion imaging can accurately assess relative reductions in regional myocardial blood flow and identify hemodynamically significant coronary artery disease. Models can be used to quantify myocardial blood flow (in milliliters/minute/gram) on the basis of dynamic signal changes within the myocardium and left ventricular cavity. Although the mathematical modeling involved in this type of analysis adds complexity, the benefits of absolute blood flow quantification might improve clinical diagnosis and have important implications for cardiovascular research.

Original languageEnglish (US)
Pages (from-to)761-770
Number of pages10
JournalJACC: Cardiovascular Imaging
Volume2
Issue number6
DOIs
StatePublished - Jun 2009

Keywords

  • blood flow quantification
  • cardiac magnetic resonance
  • gadolinium
  • myocardial perfusion
  • quantitative modeling

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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