Quantification of Absolute Myocardial Blood Flow by Magnetic Resonance Perfusion Imaging

Daniel C. Lee; Nils P. Johnson

doi:10.1016/j.jcmg.2009.04.003

Quantification of Absolute Myocardial Blood Flow by Magnetic Resonance Perfusion Imaging

Daniel C. Lee^*, Nils P. Johnson

^*Corresponding author for this work

Medicine, Cardiology Division

Research output: Contribution to journal › Review article › peer-review

60 Scopus citations

Abstract

By serially imaging the myocardium during the initial transit of gadolinium contrast, magnetic resonance perfusion imaging can accurately assess relative reductions in regional myocardial blood flow and identify hemodynamically significant coronary artery disease. Models can be used to quantify myocardial blood flow (in milliliters/minute/gram) on the basis of dynamic signal changes within the myocardium and left ventricular cavity. Although the mathematical modeling involved in this type of analysis adds complexity, the benefits of absolute blood flow quantification might improve clinical diagnosis and have important implications for cardiovascular research.

Original language	English (US)
Pages (from-to)	761-770
Number of pages	10
Journal	JACC: Cardiovascular Imaging
Volume	2
Issue number	6
DOIs	https://doi.org/10.1016/j.jcmg.2009.04.003
State	Published - Jun 2009

Keywords

blood flow quantification
cardiac magnetic resonance
gadolinium
myocardial perfusion
quantitative modeling

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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10.1016/j.jcmg.2009.04.003

Cite this

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title = "Quantification of Absolute Myocardial Blood Flow by Magnetic Resonance Perfusion Imaging",

abstract = "By serially imaging the myocardium during the initial transit of gadolinium contrast, magnetic resonance perfusion imaging can accurately assess relative reductions in regional myocardial blood flow and identify hemodynamically significant coronary artery disease. Models can be used to quantify myocardial blood flow (in milliliters/minute/gram) on the basis of dynamic signal changes within the myocardium and left ventricular cavity. Although the mathematical modeling involved in this type of analysis adds complexity, the benefits of absolute blood flow quantification might improve clinical diagnosis and have important implications for cardiovascular research.",

keywords = "blood flow quantification, cardiac magnetic resonance, gadolinium, myocardial perfusion, quantitative modeling",

author = "Lee, {Daniel C.} and Johnson, {Nils P.}",

note = "Funding Information: This work was supported by an award from the American Heart Association, the Northwestern Memorial Foundation, the Feinberg Cardiovascular Research Institute, and the Department of Medicine, Northwestern University Feinberg School of Medicine. Dr. Lee has received research grant support from St. Jude Medical (significant) and consulting fees from St. Jude Medical (modest) and Siemens Medical Solutions (modest). ",

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AU - Johnson, Nils P.

N1 - Funding Information: This work was supported by an award from the American Heart Association, the Northwestern Memorial Foundation, the Feinberg Cardiovascular Research Institute, and the Department of Medicine, Northwestern University Feinberg School of Medicine. Dr. Lee has received research grant support from St. Jude Medical (significant) and consulting fees from St. Jude Medical (modest) and Siemens Medical Solutions (modest).

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Y1 - 2009/6

N2 - By serially imaging the myocardium during the initial transit of gadolinium contrast, magnetic resonance perfusion imaging can accurately assess relative reductions in regional myocardial blood flow and identify hemodynamically significant coronary artery disease. Models can be used to quantify myocardial blood flow (in milliliters/minute/gram) on the basis of dynamic signal changes within the myocardium and left ventricular cavity. Although the mathematical modeling involved in this type of analysis adds complexity, the benefits of absolute blood flow quantification might improve clinical diagnosis and have important implications for cardiovascular research.

AB - By serially imaging the myocardium during the initial transit of gadolinium contrast, magnetic resonance perfusion imaging can accurately assess relative reductions in regional myocardial blood flow and identify hemodynamically significant coronary artery disease. Models can be used to quantify myocardial blood flow (in milliliters/minute/gram) on the basis of dynamic signal changes within the myocardium and left ventricular cavity. Although the mathematical modeling involved in this type of analysis adds complexity, the benefits of absolute blood flow quantification might improve clinical diagnosis and have important implications for cardiovascular research.

KW - blood flow quantification

KW - cardiac magnetic resonance

KW - gadolinium

KW - myocardial perfusion

KW - quantitative modeling

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Quantification of Absolute Myocardial Blood Flow by Magnetic Resonance Perfusion Imaging

Abstract

Keywords

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