Abstract
By serially imaging the myocardium during the initial transit of gadolinium contrast, magnetic resonance perfusion imaging can accurately assess relative reductions in regional myocardial blood flow and identify hemodynamically significant coronary artery disease. Models can be used to quantify myocardial blood flow (in milliliters/minute/gram) on the basis of dynamic signal changes within the myocardium and left ventricular cavity. Although the mathematical modeling involved in this type of analysis adds complexity, the benefits of absolute blood flow quantification might improve clinical diagnosis and have important implications for cardiovascular research.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 761-770 |
| Number of pages | 10 |
| Journal | JACC: Cardiovascular Imaging |
| Volume | 2 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 2009 |
Funding
This work was supported by an award from the American Heart Association, the Northwestern Memorial Foundation, the Feinberg Cardiovascular Research Institute, and the Department of Medicine, Northwestern University Feinberg School of Medicine. Dr. Lee has received research grant support from St. Jude Medical (significant) and consulting fees from St. Jude Medical (modest) and Siemens Medical Solutions (modest).
Keywords
- blood flow quantification
- cardiac magnetic resonance
- gadolinium
- myocardial perfusion
- quantitative modeling
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Radiology Nuclear Medicine and imaging
