Quantification of myocardial perfusion using multi-detector computed tomography: Validation against invasive coronary angiography

N. Kachenoura, T. Gaspar, J. A. Lodato, D. M.E. Bardo, B. Newby, S. Gips, N. Peled, R. M. Lang, V. Mor-Avi*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

While CT coronary angiography (CTCA) has been validated, the potential of CT to evaluate perfusion has not been explored. We sought to: (1) develop and test a technique for quantitative assessment of myocardial perfusion from CT images, (2) identify the underlying causes of perfusion abnormalities detected by CT, (3) determine the added diagnostic value of CT perfusion. We studied 84 consecutive patients undergoing clinical CTCA. Accuracy of automated detection of perfusion abnormalities was determined against invasive coronary angiography findings combined with known prior myocardial infarction (MI). Perfusion abnormalities were detected in 29/64 patients in 47 vascular territories, of which 36 were confirmed as abnormal. Of these 36, 10 were associated with prior MI, while 26 corresponded to significant stenosis. The addition of perfusion to CTCA improved its diagnostic accuracy. In conclusion, myocardial perfusion is a potentially valuable addition to CT tools for the evaluation of coronary artery disease without additional cost in radiation dose or contrast load.

Original languageEnglish (US)
Title of host publicationComputers in Cardiology 2008, CAR
Pages5-8
Number of pages4
DOIs
StatePublished - 2008
EventComputers in Cardiology 2008, CAR - Bologna, Italy
Duration: Sep 14 2008Sep 17 2008

Publication series

NameComputers in Cardiology
Volume35
ISSN (Print)0276-6574

Other

OtherComputers in Cardiology 2008, CAR
Country/TerritoryItaly
CityBologna
Period9/14/089/17/08

ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine

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