Quantification of myocardial segmental function in acute and chronic ischemic heart disease and implications for cardiovascular cell therapy trials: A review from the NHLBI-cardiovascular cell therapy research network

John W. Petersen, John R. Forder, James D. Thomas, Lemuel A. Moyé, Mark Lawson, Catalin Loghin, Jay H. Traverse, Sarah Baraniuk, Guilherme Silva, Carl J. Pepine

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Global left ventricular (LV) ejection fraction (LVEF) has been used as a measure of improvement in LV function following cell therapy. Although the impact of cell therapy on LVEF in short- and long-term follow-up has been generally positive, there is concern that research evaluating regional therapeutics (e.g., cell or gene therapy) may require analysis of regional LV function localized to the site of intervention. Regional LV assessment is traditionally performed with qualitative or quantitative analysis of wall thickening within 16 myocardial segments, but advances in noninvasive imaging permit an increasingly more detailed and accurate evaluation of LV function. Wall-thickness measurements can now include evaluation of over 1,000 myocardial segments. In addition to higher resolution measures of wall thickening, automated assessments of myocardial segment deformation, such as strain imaging, exist. Strain imaging allows for direct evaluation of the mechanical properties that may improve following regional therapeutic intervention. Improvements in regional LV function may also be assessed by determining regional ejection fraction (EF). Regional EF offers the advantage of summarizing the end result of all of the complex deformations in the adjacent myocardial segments. Although regional EF and strain imaging, as compared with wall thickening, enhance detection of improvement in complex measures of regional myocardial function, it remains unclear whether such measures are better able to predict meaningful improvement in clinical outcomes.

Original languageEnglish (US)
Pages (from-to)671-679
Number of pages9
JournalJACC: Cardiovascular Imaging
Volume4
Issue number6
DOIs
StatePublished - Jun 2011

Keywords

  • left ventricular function
  • regional ejection fraction
  • regional ventricular function
  • strain imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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