TY - JOUR
T1 - Quantification of nanoscale density fluctuations using electron microscopy
T2 - Light-localization properties of biological cells
AU - Pradhan, Prabhakar
AU - Damania, Dhwanil
AU - Joshi, Hrushikesh M.
AU - Turzhitsky, Vladimir
AU - Subramanian, Hariharan
AU - Roy, Hemant K.
AU - Taflove, Allen
AU - Dravid, Vinayak P.
AU - Backman, Vadim
N1 - Funding Information:
This work was supported by NIH grants (Grant Nos. R01EB003682, R01CA128641, and U54CA143869) and NSF Grant No. CBET-0937987. V.P.D. acknowledges support from NIH/NCI PS-OC Grant No. DMR-0603184 and NIH-CCNE (Northwestern) Grant No. U54CA119341. Parts of the experiments were done at the EPIC/NIFTI facility of the NUANCE Centre (supported by NSF-NSEC, NSF-MRSEC, Keck Foundation, the State of Illinois, and Northwestern University) at Northwestern University. P.P. thanks S. Sridhar (Northeastern University, Boston) for many insightful discussions.
PY - 2010/12/13
Y1 - 2010/12/13
N2 - We report a study of the nanoscale mass-density fluctuations of heterogeneous optical dielectric media, including nanomaterials and biological cells, by quantifying their nanoscale light-localization properties. Transmission electron microscope images of the media are used to construct corresponding effective disordered optical lattices. Light-localization properties are studied by the statistical analysis of the inverse participation ratio (IPR) of the localized eigenfunctions of these optical lattices at the nanoscale. We validated IPR analysis using nanomaterials as models of disordered systems fabricated from dielectric nanoparticles. As an example, we then applied such analysis to distinguish between cells with different degrees of aggressive malignancy.
AB - We report a study of the nanoscale mass-density fluctuations of heterogeneous optical dielectric media, including nanomaterials and biological cells, by quantifying their nanoscale light-localization properties. Transmission electron microscope images of the media are used to construct corresponding effective disordered optical lattices. Light-localization properties are studied by the statistical analysis of the inverse participation ratio (IPR) of the localized eigenfunctions of these optical lattices at the nanoscale. We validated IPR analysis using nanomaterials as models of disordered systems fabricated from dielectric nanoparticles. As an example, we then applied such analysis to distinguish between cells with different degrees of aggressive malignancy.
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U2 - 10.1063/1.3524523
DO - 10.1063/1.3524523
M3 - Article
C2 - 21221251
AN - SCOPUS:78650387325
SN - 0003-6951
VL - 97
JO - Applied Physics Letters
JF - Applied Physics Letters
IS - 24
M1 - 243704
ER -