Normal quantities of G(M 1) β-galactosidase cross reacting material (CRM) (0.31-0.47 μg/mg protein) were detected by a sensitive radial immunodiffusion assay in skin fibroblast from patients with G(M 1) gangliosidosis type 1 and adult variants, whereas elevated levels were found in G(M 1) gangliosidosis type 2 (0.41-0.72 μg/mg protein). The specific activity of the immunologically CRM towards G(M 1) ganglioside of normal fibroblasts was about 500 times that of type 1, 100 times that of type 2, and 30 times that of the adult variants.
|Original language||English (US)|
|Number of pages||6|
|Journal||American Journal of Human Genetics|
|State||Published - Dec 1 1977|
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