Quantitative analysis of en face spectral-domain optical coherence tomography imaging in polypoidal choroidal vasculopathy

Joseph M. Simonett; Errol W. Chan; Jonathan Chou; Dimitra Skondra; Daniel Colon; Caroline K. Chee; Gopal Lingam; Amani A. Fawzi

doi:10.3928/23258160-20170130-06

Quantitative analysis of en face spectral-domain optical coherence tomography imaging in polypoidal choroidal vasculopathy

Joseph M. Simonett, Errol W. Chan, Jonathan Chou, Dimitra Skondra, Daniel Colon, Caroline K. Chee, Gopal Lingam, Amani A. Fawzi^*

^*Corresponding author for this work

Ophthalmology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background and Objective: Spectral-domain optical coherence tomography (SD-OCT) imaging can be used to visualize polypoidal choroidal vasculopathy (PCV) lesions in the en face plane. Here, the authors describe a novel lesion quantifcation technique and compare PCV lesion area measurements and morphology before and after anti-vascular endothelial growth factor (VEGF) treatment. PATIENTS AND METHODS: Volumetric SD-OCT scans in eyes with PCV before and after induction anti-VEGF therapy were retrospectively analyzed. En face SD-OCT images were generated and a pixel intensity thresholding process was used to quantify total lesion area. RESULTS: Thirteen eyes with PCV were analyzed. En face SD-OCT PCV lesion area quantifcation showed good intergrader reliability (intraclass correlation coeffcient = 0.944). Total PCV lesion area was signifcantly reduced after anti-VEGF therapy (2.22 mm² vs. 2.73 mm²; P =.02). The overall geographic pattern of the branching vascular network was typically preserved. CONCLUSION: PCV lesion area analysis using en face SD-OCT is a reproducible tool that can quantify treatment related changes.

Original language	English (US)
Pages (from-to)	126-133
Number of pages	8
Journal	Ophthalmic Surgery Lasers and Imaging Retina
Volume	48
Issue number	2
DOIs	https://doi.org/10.3928/23258160-20170130-06
State	Published - Feb 2017

ASJC Scopus subject areas

Surgery
Ophthalmology

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@article{f1f9a95e5a884a9a8941b9f28be6b57e,

title = "Quantitative analysis of en face spectral-domain optical coherence tomography imaging in polypoidal choroidal vasculopathy",

abstract = "Background and Objective: Spectral-domain optical coherence tomography (SD-OCT) imaging can be used to visualize polypoidal choroidal vasculopathy (PCV) lesions in the en face plane. Here, the authors describe a novel lesion quantifcation technique and compare PCV lesion area measurements and morphology before and after anti-vascular endothelial growth factor (VEGF) treatment. PATIENTS AND METHODS: Volumetric SD-OCT scans in eyes with PCV before and after induction anti-VEGF therapy were retrospectively analyzed. En face SD-OCT images were generated and a pixel intensity thresholding process was used to quantify total lesion area. RESULTS: Thirteen eyes with PCV were analyzed. En face SD-OCT PCV lesion area quantifcation showed good intergrader reliability (intraclass correlation coeffcient = 0.944). Total PCV lesion area was signifcantly reduced after anti-VEGF therapy (2.22 mm2 vs. 2.73 mm2; P =.02). The overall geographic pattern of the branching vascular network was typically preserved. CONCLUSION: PCV lesion area analysis using en face SD-OCT is a reproducible tool that can quantify treatment related changes.",

author = "Simonett, {Joseph M.} and Chan, {Errol W.} and Jonathan Chou and Dimitra Skondra and Daniel Colon and Chee, {Caroline K.} and Gopal Lingam and Fawzi, {Amani A.}",

year = "2017",

month = feb,

doi = "10.3928/23258160-20170130-06",

language = "English (US)",

volume = "48",

pages = "126--133",

journal = "Ophthalmic Surgery Lasers and Imaging Retina",

issn = "2325-8160",

publisher = "Slack Incorporated",

number = "2",

}

Quantitative analysis of en face spectral-domain optical coherence tomography imaging in polypoidal choroidal vasculopathy. / Simonett, Joseph M.; Chan, Errol W.; Chou, Jonathan; Skondra, Dimitra; Colon, Daniel; Chee, Caroline K.; Lingam, Gopal; Fawzi, Amani A.

In: Ophthalmic Surgery Lasers and Imaging Retina, Vol. 48, No. 2, 02.2017, p. 126-133.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Quantitative analysis of en face spectral-domain optical coherence tomography imaging in polypoidal choroidal vasculopathy

AU - Simonett, Joseph M.

AU - Chan, Errol W.

AU - Chou, Jonathan

AU - Skondra, Dimitra

AU - Colon, Daniel

AU - Chee, Caroline K.

AU - Lingam, Gopal

AU - Fawzi, Amani A.

PY - 2017/2

Y1 - 2017/2

N2 - Background and Objective: Spectral-domain optical coherence tomography (SD-OCT) imaging can be used to visualize polypoidal choroidal vasculopathy (PCV) lesions in the en face plane. Here, the authors describe a novel lesion quantifcation technique and compare PCV lesion area measurements and morphology before and after anti-vascular endothelial growth factor (VEGF) treatment. PATIENTS AND METHODS: Volumetric SD-OCT scans in eyes with PCV before and after induction anti-VEGF therapy were retrospectively analyzed. En face SD-OCT images were generated and a pixel intensity thresholding process was used to quantify total lesion area. RESULTS: Thirteen eyes with PCV were analyzed. En face SD-OCT PCV lesion area quantifcation showed good intergrader reliability (intraclass correlation coeffcient = 0.944). Total PCV lesion area was signifcantly reduced after anti-VEGF therapy (2.22 mm2 vs. 2.73 mm2; P =.02). The overall geographic pattern of the branching vascular network was typically preserved. CONCLUSION: PCV lesion area analysis using en face SD-OCT is a reproducible tool that can quantify treatment related changes.

AB - Background and Objective: Spectral-domain optical coherence tomography (SD-OCT) imaging can be used to visualize polypoidal choroidal vasculopathy (PCV) lesions in the en face plane. Here, the authors describe a novel lesion quantifcation technique and compare PCV lesion area measurements and morphology before and after anti-vascular endothelial growth factor (VEGF) treatment. PATIENTS AND METHODS: Volumetric SD-OCT scans in eyes with PCV before and after induction anti-VEGF therapy were retrospectively analyzed. En face SD-OCT images were generated and a pixel intensity thresholding process was used to quantify total lesion area. RESULTS: Thirteen eyes with PCV were analyzed. En face SD-OCT PCV lesion area quantifcation showed good intergrader reliability (intraclass correlation coeffcient = 0.944). Total PCV lesion area was signifcantly reduced after anti-VEGF therapy (2.22 mm2 vs. 2.73 mm2; P =.02). The overall geographic pattern of the branching vascular network was typically preserved. CONCLUSION: PCV lesion area analysis using en face SD-OCT is a reproducible tool that can quantify treatment related changes.

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