Quantitative analysis of en face spectral-domain optical coherence tomography imaging in polypoidal choroidal vasculopathy

Joseph M. Simonett, Errol W. Chan, Jonathan Chou, Dimitra Skondra, Daniel Colon, Caroline K. Chee, Gopal Lingam, Amani A. Fawzi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background and Objective: Spectral-domain optical coherence tomography (SD-OCT) imaging can be used to visualize polypoidal choroidal vasculopathy (PCV) lesions in the en face plane. Here, the authors describe a novel lesion quantifcation technique and compare PCV lesion area measurements and morphology before and after anti-vascular endothelial growth factor (VEGF) treatment. PATIENTS AND METHODS: Volumetric SD-OCT scans in eyes with PCV before and after induction anti-VEGF therapy were retrospectively analyzed. En face SD-OCT images were generated and a pixel intensity thresholding process was used to quantify total lesion area. RESULTS: Thirteen eyes with PCV were analyzed. En face SD-OCT PCV lesion area quantifcation showed good intergrader reliability (intraclass correlation coeffcient = 0.944). Total PCV lesion area was signifcantly reduced after anti-VEGF therapy (2.22 mm2 vs. 2.73 mm2; P =.02). The overall geographic pattern of the branching vascular network was typically preserved. CONCLUSION: PCV lesion area analysis using en face SD-OCT is a reproducible tool that can quantify treatment related changes.

Original languageEnglish (US)
Pages (from-to)126-133
Number of pages8
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume48
Issue number2
DOIs
StatePublished - Feb 2017

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

Fingerprint

Dive into the research topics of 'Quantitative analysis of en face spectral-domain optical coherence tomography imaging in polypoidal choroidal vasculopathy'. Together they form a unique fingerprint.

Cite this