Quantitative analysis of mucosal tissues in patients using light scattering spectroscopy

Lev T. Perelman*, George Zonios, Vadim Backman, Rajan Gurjar, Irving Itzkan, Ramachandra R. Dasari, Jacques Van Dam, Michael S. Feld

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


We presented two approaches for separating a diffusive component of the backscattered signal originated in deep tissue layers and a non-diffusive single backscattering component which backscattered from a thin epithelial layer. Both approaches can be effective and have their advantages and disadvantages. The modeling technique can provide important information about hemoglobin concentration, oxygenation, and average scattering properties of the mucosal tissue. On the other hand, when applied to new tissues, it has to be adjusted to take into account tissue morphology. Also, the polarization technique can be very robust and more effective in background removal. However, it lacks extracting capabilities of the modeling technique. Both techniques can be quite valuable and compliment each other in a future clinical device.

Original languageEnglish (US)
Pages (from-to)474-479
Number of pages6
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - Dec 1 1999

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics


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