Quantitative and qualitative tests for urinary luteinizing hormone: Comparison in spontaneous and clomiphene-citrate-treated cycles

K. L. Ponto, R. B. Barnes*, J. A. Holt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

A study was performed to evaluate conditions in which false-positive and -negative predictions of ovulation occur with qualitative urinary luteinizing hormone (LH) tests. Three urine specimens and a serum sample were collected daily for LH determination from five anovulatory women treated with clomiphene citrate and from six spontaneously cycling women. The urinary LH was determined with one quantitative and three qualitative tests, and the serum LH was determined with a quantitative assay. Ovulation was determined with transvaginal ultrasound and a serum progesterone level on day 22 of the menstrual cycle. There were six ovulatory and five anovulatory cycles. In those 11 cycles the qualitative urinary LH tests were falsely positive twice and falsely negative thrice. All the false-positive and -negative tests except for one occurred when the quantitative urinary LH was 24-28 mIU/mL. Two false-positive tests occurred one to two days after clomiphene administration. Two false-negative tests occurred in a cycle in which follicular development appeared suboptimal, and one occurred in a cycle with a brief urinary LH surge.

Original languageEnglish (US)
Pages (from-to)1051-1054
Number of pages4
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume35
Issue number11
StatePublished - Dec 1 1990

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Fingerprint Dive into the research topics of 'Quantitative and qualitative tests for urinary luteinizing hormone: Comparison in spontaneous and clomiphene-citrate-treated cycles'. Together they form a unique fingerprint.

Cite this