QUANTITATIVE ASSESSMENT OF CUMULATIVE DAMAGE FROM REPETITIVE EXPOSURES TO SUBERYTHEMOGENIC DOSES OF UVA IN HUMAN SKIN

R. M. Lavker; D. A. Veres; C. J. Irwin; K. H. KAIDBEY

doi:10.1111/j.1751-1097.1995.tb05280.x

QUANTITATIVE ASSESSMENT OF CUMULATIVE DAMAGE FROM REPETITIVE EXPOSURES TO SUBERYTHEMOGENIC DOSES OF UVA IN HUMAN SKIN

R. M. Lavker, D. A. Veres, C. J. Irwin, K. H. KAIDBEY^*

^*Corresponding author for this work

Dermatology

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

Abstract— Daily exposures to relatively small suberythemogenic fluences of UVA (50–200 kj/m²) for 8 days resulted in cumulative morphological skin alterations indicative of early tissue injury. Histologically, irradiated skin revealed epidermal hyperplasia, inflammation and deposition of lysozyme along the dermal elastic fiber network. Sunburn cells were also present within the epidermis. These changes were quantified by image analysis and were found to be related to the cumulative UVA fluence. A long UVA waveband (UVAI, 340–400 nm) was as effective as a broad UVA band (320–400 nm), suggesting that these changes are induced by longer UVA wavelengths.

Original language	English (US)
Pages (from-to)	348-352
Number of pages	5
Journal	Photochemistry and Photobiology
Volume	62
Issue number	2
DOIs	https://doi.org/10.1111/j.1751-1097.1995.tb05280.x
State	Published - Aug 1995

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry

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10.1111/j.1751-1097.1995.tb05280.x

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title = "QUANTITATIVE ASSESSMENT OF CUMULATIVE DAMAGE FROM REPETITIVE EXPOSURES TO SUBERYTHEMOGENIC DOSES OF UVA IN HUMAN SKIN",

abstract = "Abstract— Daily exposures to relatively small suberythemogenic fluences of UVA (50–200 kj/m2) for 8 days resulted in cumulative morphological skin alterations indicative of early tissue injury. Histologically, irradiated skin revealed epidermal hyperplasia, inflammation and deposition of lysozyme along the dermal elastic fiber network. Sunburn cells were also present within the epidermis. These changes were quantified by image analysis and were found to be related to the cumulative UVA fluence. A long UVA waveband (UVAI, 340–400 nm) was as effective as a broad UVA band (320–400 nm), suggesting that these changes are induced by longer UVA wavelengths.",

author = "Lavker, {R. M.} and Veres, {D. A.} and Irwin, {C. J.} and KAIDBEY, {K. H.}",

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AU - Veres, D. A.

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N2 - Abstract— Daily exposures to relatively small suberythemogenic fluences of UVA (50–200 kj/m2) for 8 days resulted in cumulative morphological skin alterations indicative of early tissue injury. Histologically, irradiated skin revealed epidermal hyperplasia, inflammation and deposition of lysozyme along the dermal elastic fiber network. Sunburn cells were also present within the epidermis. These changes were quantified by image analysis and were found to be related to the cumulative UVA fluence. A long UVA waveband (UVAI, 340–400 nm) was as effective as a broad UVA band (320–400 nm), suggesting that these changes are induced by longer UVA wavelengths.

AB - Abstract— Daily exposures to relatively small suberythemogenic fluences of UVA (50–200 kj/m2) for 8 days resulted in cumulative morphological skin alterations indicative of early tissue injury. Histologically, irradiated skin revealed epidermal hyperplasia, inflammation and deposition of lysozyme along the dermal elastic fiber network. Sunburn cells were also present within the epidermis. These changes were quantified by image analysis and were found to be related to the cumulative UVA fluence. A long UVA waveband (UVAI, 340–400 nm) was as effective as a broad UVA band (320–400 nm), suggesting that these changes are induced by longer UVA wavelengths.

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QUANTITATIVE ASSESSMENT OF CUMULATIVE DAMAGE FROM REPETITIVE EXPOSURES TO SUBERYTHEMOGENIC DOSES OF UVA IN HUMAN SKIN

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