Quantitative assessment of synovitis in Legg-Calvé-Perthes disease using gadolinium-enhanced MRI

David C. Neal, Jack C. O'Brien, Jamie Burgess, Chanhee Jo, Harry K.W. Kim*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


A quantitative method to assess hip synovitis in Legg-Calvé-Perthes disease (LCPD) is not currently available. To develop this method, the areas of synovial enhancement on gadolinium-enhanced MRI (Gd-MRI) were measured by two independent observers. The volume of synovial enhancement was significantly increased in the initial and the fragmentation stages of LCPD (Waldenström stages I and II), with a persistence of synovitis into the reossification stage (stage III). The Gd-MRI method had high interobserver and intraobserver agreements and may serve as a useful method to monitor the effect of various treatments on hip synovitis in LCPD.

Original languageEnglish (US)
Pages (from-to)89-94
Number of pages6
JournalJournal of Pediatric Orthopaedics Part B
Issue number2
StatePublished - Mar 6 2015


  • avascular necrosis
  • gadolinium-enhanced MRI
  • hip synovitis
  • Legg-Calvé-Perthes disease
  • osteonecrosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Orthopedics and Sports Medicine


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