Quantitative characterization of biological tissue using optical spectroscopy

Irene Georgakoudi, Jason T. Motz, Vadim Backman, George Angheloiu, Abigail S. Haka, Markus Müller, Michael S. Feld

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations


Spectroscopic techniques examine different types of light–tissue interactions and provide biochemical and morphological information at the molecular, cell, and tissue levels in a noninvasive way. Because light delivery and collection are compatible with optical fibers and data analysis can be achieved in real time, spectroscopic information can serve as a powerful tool for assessing the state of tissue in vivo thus, guiding surgery or biopsy or monitoring the effects of treatment. Ultimately, optical techniques could eliminate the need for biopsy, at least in some cases, and allow for a single triage visit during which detection and treatment of a lesion could be combined. However, to optimize the use of optical methods in disease detection and treatment, it is important to understand and quantify the information provided by the detected optical signals. Spectroscopic techniques are ideal for this purpose.

Original languageEnglish (US)
Title of host publicationBiomedical Photonics
Subtitle of host publicationHandbook
PublisherCRC Press
ISBN (Electronic)9780203008997
ISBN (Print)0849311160, 9780849311161
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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