Quantitative evaluation of a hydrophilic matrix intravaginal ring for the sustained delivery of tenofovir

Justin T. Clark, Todd J. Johnson, Meredith R. Clark, Joel S. Nebeker, Judit Fabian, Anthony L. Tuitupou, Satya Ponnapalli, Eric M. Smith, David R. Friend, Patrick F. Kiser*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

In vitro testing and quantitative analysis of a matrix, hydrophilic polyether urethane (HPEU) intravaginal ring (IVR) for sustained delivery of the anti-HIV agent tenofovir (TFV) are described. To aid in device design, we employed a pseudo-steady-state diffusion model to describe drug release, as well as an elastic mechanical model for ring compression to predict mechanical properties. TFV-HPEU IVRs of varying sizes and drug loadings were fabricated by hot-melt extrusion and injection molding. In vitro release rates of TFV were measured at 37 °C and pH 4.2 for 30 or 90 days, during which times IVR mechanical properties and swelling kinetics were monitored. Experimental data for drug release and mechanical properties were compared to model predictions. IVRs loaded with 21% TFV (w/w) released greater than 2 mg TFV per day for 90 days. The diffusion model predicted 90 day release data by extrapolating forward from the first 7 days of data. Mechanical properties of IVRs were similar to NuvaRing®, although the matrix elastic modulus decreased up to three-fold following hydration. This is the first vaginal dosage form to provide sustained delivery of milligram quantities of TFV for 90 days. Drug release and mechanical properties were approximated by analytical models, which may prove useful for the continuing development of IVRs for HIV prevention or other women's health indications.

Original languageEnglish (US)
Pages (from-to)240-248
Number of pages9
JournalJournal of Controlled Release
Volume163
Issue number2
DOIs
StatePublished - Oct 28 2012

Keywords

  • Drug release modeling
  • Hydrophilic polyether urethane
  • Intravaginal ring
  • Microbicides for HIV prevention
  • Tenofovir

ASJC Scopus subject areas

  • Pharmaceutical Science

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