TY - JOUR
T1 - Quantitative imaging biomarkers for the evaluation of cardiovascular complications in type 2 diabetes mellitus
AU - Lin, Kai
AU - Lloyd-Jones, Donald M.
AU - Li, Debiao
AU - Carr, James C.
PY - 2014
Y1 - 2014
N2 - Type 2 diabetes mellitus (T2DM) is a prevalent condition in aged populations. Cardiovascular diseases are leading causes of death and disability in patients with T2DM. Traditional strategies for controlling the cardiovascular complications of diabetes primarily target a cluster of well-defined risk factors, such as hyperglycemia, lipid disorders and hypertension. However, there is controversy over some recent clinical trials aimed at evaluating efficacy of intensive treatments for T2DM. As a powerful tool for quantitative cardiovascular risk estimation, multi-disciplinary cardiovascular imaging have been applied to detect and quantify morphological and functional abnormalities in the cardiovascular system. Quantitative imaging biomarkers acquired with advanced imaging procedures are expected to provide new insights to stratify absolute cardiovascular risks and reduce the overall costs of health care for people with T2DM by facilitating the selection of optimal therapies. This review discusses principles of state-of-the-art cardiovascular imaging techniques and compares applications of those techniques in various clinical circumstances. Individuals measurements of cardiovascular disease burdens from multiple aspects, which are closely related to existing biomarkers and clinical outcomes, are recommended as promising candidates for quantitative imaging biomarkers to assess the responses of the cardiovascular system during diabetic regimens.
AB - Type 2 diabetes mellitus (T2DM) is a prevalent condition in aged populations. Cardiovascular diseases are leading causes of death and disability in patients with T2DM. Traditional strategies for controlling the cardiovascular complications of diabetes primarily target a cluster of well-defined risk factors, such as hyperglycemia, lipid disorders and hypertension. However, there is controversy over some recent clinical trials aimed at evaluating efficacy of intensive treatments for T2DM. As a powerful tool for quantitative cardiovascular risk estimation, multi-disciplinary cardiovascular imaging have been applied to detect and quantify morphological and functional abnormalities in the cardiovascular system. Quantitative imaging biomarkers acquired with advanced imaging procedures are expected to provide new insights to stratify absolute cardiovascular risks and reduce the overall costs of health care for people with T2DM by facilitating the selection of optimal therapies. This review discusses principles of state-of-the-art cardiovascular imaging techniques and compares applications of those techniques in various clinical circumstances. Individuals measurements of cardiovascular disease burdens from multiple aspects, which are closely related to existing biomarkers and clinical outcomes, are recommended as promising candidates for quantitative imaging biomarkers to assess the responses of the cardiovascular system during diabetic regimens.
KW - Cardiovascular complications
KW - Imaging biomarkers
KW - T2DM
UR - http://www.scopus.com/inward/record.url?scp=84896704019&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896704019&partnerID=8YFLogxK
U2 - 10.1016/j.jdiacomp.2013.09.008
DO - 10.1016/j.jdiacomp.2013.09.008
M3 - Review article
C2 - 24309215
AN - SCOPUS:84896704019
SN - 1056-8727
VL - 28
SP - 234
EP - 242
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
IS - 2
ER -
