Quantitative measurement of breast carcinoma fibrosis for the prediction in the risk of bone metastasis

Chong Sun, Bin Wang, Jianmin Li*, Junjie Shangguan, Matteo Figini, Kang Zhou, Liang Pan, Quanhong Ma, Zhuoli Zhang

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Background: Previous studies have shown the poor prognosis of metastatic breast cancer including bone metastasis. The early prediction and intervention of invasive breast carcinoma with bone metastasis are crucial to the outcomes of patients. The purpose of our study is to test the hypothesis that the collagen deposition of primary breast cancer can be used as a quantitative biomarker for the early prediction of bone metastasis. Methods: A total of sixty breast cancer patients were included in our study, and the surgical specimens of these patients were divided into three groups: patients with no metastasis (group 1), lymph node metastasis (group 2), and bone metastasis (group 3). Masson’s trichrome staining and hematoxylin and eosin staining were applied to all primary breast cancers. Collagen area percentage and tumor cell measurement of each sample were measured by HistoQuest software. Results: Measurement results of collagen area percentage (%) in primary breast tumors were 32.39 ± 13.30, 25.37 ± 11.10, and 22.71 ± 8.91 for groups 1, 2, and 3, respectively. The corresponding P values were 0.0779 (group 1 vs. group 2), 0.4086 (group 2 vs. group 3), and 0.0102 (group 1 vs. group 3). The correlation between collagen area percentage and tumor cell measurement were group 1 (P = 0.5927, r =-0.1273), group 2 (P = 0.5711, r =-0.1348), and group 3 (P = 0.0003, r =-0.7253). Conclusions: The collagen deposition of primary breast cancer can be used as a quantitative biomarker for the early prediction of bone metastasis.

Original languageEnglish (US)
Article numberAJTR0074054
Pages (from-to)1852-1859
Number of pages8
JournalAmerican Journal of Translational Research
Volume10
Issue number6
StatePublished - 2018

Keywords

  • Bone metastasis
  • Collagen deposition
  • Early prediction
  • Invasive breast carcinoma

ASJC Scopus subject areas

  • Molecular Medicine
  • Clinical Biochemistry
  • Cancer Research

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    Sun, C., Wang, B., Li, J., Shangguan, J., Figini, M., Zhou, K., Pan, L., Ma, Q., & Zhang, Z. (2018). Quantitative measurement of breast carcinoma fibrosis for the prediction in the risk of bone metastasis. American Journal of Translational Research, 10(6), 1852-1859. [AJTR0074054].