TY - JOUR
T1 - Quantitative measurement of cartilage volume with automatic cartilage segmentation in knee osteoarthritis
AU - Hou, Wenjing
AU - Zhao, Jun
AU - He, Rui
AU - Li, Jing
AU - Ou, Yuan
AU - Du, Mingshan
AU - Xiong, Xuanqi
AU - Xie, Bing
AU - Li, Lian
AU - Zhou, Xiaoyue
AU - Zuo, Panli
AU - Raithel, Esther
AU - Zhang, Zhuoli
AU - Chen, Wei
N1 - Funding Information:
Research reported was supported by the National Key Research and Development plan of China (NO. 2016YFC1100501) and The Science and Technology Innovation Program of Social Undertakings and People’s Livelihood Security of Chongqing Science and Technology Commission (cstc2016shms-ztzx10002). Acknowledgments
Publisher Copyright:
© 2020, International League of Associations for Rheumatology (ILAR).
PY - 2021/5
Y1 - 2021/5
N2 - Purpose: To determine the reproducibility of the automatic cartilage segmentation method using a prototype KneeCaP software (version 1.3; Siemens Healthcare, Erlangen, Germany) and to compare the difference in cartilage volume (CV) between the normal knee joint and knee osteoarthritis (KOA) of different degrees by using the above software. Materials and methods: The study included 62 subjects with knee OA and 29 healthy control subjects. The cartilage lesion patients were divided into a mild-to-moderate OA group (n = 29) and severe OA group (n = 33). Automatic cartilage segmentation was performed on all the subjects, and among them, 19 knee cases were randomly selected to also do the manual cartilage segmentation. Statistical significance was determined with one-way analysis of variance (ANOVA), intraclass correlation coefficient (ICC), and Pearson correlation coefficient. Automatic segmentation was compared with the manual one. The relative cartilage volume percentages of the femur, tibia, and patella in the normal control/mild-to-moderate/severe OA groups were assessed. Results: Comparing the cartilage volumes derived by manual and automatic segmentation, the ICC value for the knee joint, patella, femur, or tibia was 0.784, 0.815, 0.740, and 0.797. The relative cartilage volume percentages of the femur, tibia, and patella in the normal control/mild-to-moderate/severe OA groups were 57.28%/59.30%/62.45% (femur), 25.35%/23.46%/21.84% (tibia), and 17.37%/17.24%/15.71% (patella), respectively. Compared with the normal control group, the relative tibia cartilage volume percentage was lower in the mild-to-moderate OA group and the severe OA group. Corresponding index showed a similar difference between the mild-to-moderate OA group and the severe OA group (p < 0.001). Conclusion: This study demonstrated that the relative cartilage volume percentage is correlated with the semi-quantitative systems and may be a preferred outcome measure in clinical studies of OA. Automatic cartilage segmentation using KneeCaP delivered reliable results on high-spatial-resolution 3 T MR images for the healthy, mild-moderate OA patients.Key Points• The cartilage automatic segmentation has excellent reproducibility and was not affected by inter-observer variation.• The relative cartilage volume percentage is correlated with the semi-quantitative systems and may be a preferred outcome measure in clinical studies of OA.
AB - Purpose: To determine the reproducibility of the automatic cartilage segmentation method using a prototype KneeCaP software (version 1.3; Siemens Healthcare, Erlangen, Germany) and to compare the difference in cartilage volume (CV) between the normal knee joint and knee osteoarthritis (KOA) of different degrees by using the above software. Materials and methods: The study included 62 subjects with knee OA and 29 healthy control subjects. The cartilage lesion patients were divided into a mild-to-moderate OA group (n = 29) and severe OA group (n = 33). Automatic cartilage segmentation was performed on all the subjects, and among them, 19 knee cases were randomly selected to also do the manual cartilage segmentation. Statistical significance was determined with one-way analysis of variance (ANOVA), intraclass correlation coefficient (ICC), and Pearson correlation coefficient. Automatic segmentation was compared with the manual one. The relative cartilage volume percentages of the femur, tibia, and patella in the normal control/mild-to-moderate/severe OA groups were assessed. Results: Comparing the cartilage volumes derived by manual and automatic segmentation, the ICC value for the knee joint, patella, femur, or tibia was 0.784, 0.815, 0.740, and 0.797. The relative cartilage volume percentages of the femur, tibia, and patella in the normal control/mild-to-moderate/severe OA groups were 57.28%/59.30%/62.45% (femur), 25.35%/23.46%/21.84% (tibia), and 17.37%/17.24%/15.71% (patella), respectively. Compared with the normal control group, the relative tibia cartilage volume percentage was lower in the mild-to-moderate OA group and the severe OA group. Corresponding index showed a similar difference between the mild-to-moderate OA group and the severe OA group (p < 0.001). Conclusion: This study demonstrated that the relative cartilage volume percentage is correlated with the semi-quantitative systems and may be a preferred outcome measure in clinical studies of OA. Automatic cartilage segmentation using KneeCaP delivered reliable results on high-spatial-resolution 3 T MR images for the healthy, mild-moderate OA patients.Key Points• The cartilage automatic segmentation has excellent reproducibility and was not affected by inter-observer variation.• The relative cartilage volume percentage is correlated with the semi-quantitative systems and may be a preferred outcome measure in clinical studies of OA.
KW - Cartilage
KW - Knee
KW - Osteoarthritis
KW - Segmentation
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U2 - 10.1007/s10067-020-05388-7
DO - 10.1007/s10067-020-05388-7
M3 - Article
C2 - 33026551
AN - SCOPUS:85092200877
SN - 0770-3198
VL - 40
SP - 1997
EP - 2006
JO - Clinical Rheumatology
JF - Clinical Rheumatology
IS - 5
ER -