Questioning the Role of a Neutropenic Diet following Hematopoetic Stem Cell Transplantation

Steven Trifilio*, Irene Helenowski, Meghan Giel, Barbara Gobel, Judy Pi, Deborah Greenberg, Jayesh Mehta

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

The use of a neutropenic diet (ND) after hematopoietic stem cell transplantation (HSCT) was instituted more than 30 years ago as a means of preventing infection from organisms colonizing the gastrointestinal tract. Evidence supporting this practice is lacking, however, and the actual efficacy of the ND remains unknown. Institutional policy at Northwestern Memorial Hospital discontinued the use of ND in 2006. We conducted a retrospective study of 726 consecutive HSCT recipients, 363 who received an ND and 363 who received a general hospital diet, to determine the incidence of microbiologically confirmed infections during and after transplantation. Our findings indicate a higher rate of infections in the HSCT recipients who received an ND.

Original languageEnglish (US)
Pages (from-to)1385-1390
Number of pages6
JournalBiology of Blood and Marrow Transplantation
Volume18
Issue number9
DOIs
StatePublished - Sep 2012

Keywords

  • Antibiotics
  • Infection
  • Nutrition

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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