Questioning the Role of a Neutropenic Diet following Hematopoetic Stem Cell Transplantation

Steven Trifilio; Irene Helenowski; Meghan Giel; Barbara Gobel; Judy Pi; Deborah Greenberg; Jayesh Mehta

doi:10.1016/j.bbmt.2012.02.015

Questioning the Role of a Neutropenic Diet following Hematopoetic Stem Cell Transplantation

Steven Trifilio^*, Irene Helenowski, Meghan Giel, Barbara Gobel, Judy Pi, Deborah Greenberg, Jayesh Mehta

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

The use of a neutropenic diet (ND) after hematopoietic stem cell transplantation (HSCT) was instituted more than 30 years ago as a means of preventing infection from organisms colonizing the gastrointestinal tract. Evidence supporting this practice is lacking, however, and the actual efficacy of the ND remains unknown. Institutional policy at Northwestern Memorial Hospital discontinued the use of ND in 2006. We conducted a retrospective study of 726 consecutive HSCT recipients, 363 who received an ND and 363 who received a general hospital diet, to determine the incidence of microbiologically confirmed infections during and after transplantation. Our findings indicate a higher rate of infections in the HSCT recipients who received an ND.

Original language	English (US)
Pages (from-to)	1385-1390
Number of pages	6
Journal	Biology of Blood and Marrow Transplantation
Volume	18
Issue number	9
DOIs	https://doi.org/10.1016/j.bbmt.2012.02.015
State	Published - Sep 2012

Keywords

Antibiotics
Infection
Nutrition

ASJC Scopus subject areas

Hematology
Transplantation

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10.1016/j.bbmt.2012.02.015

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abstract = "The use of a neutropenic diet (ND) after hematopoietic stem cell transplantation (HSCT) was instituted more than 30 years ago as a means of preventing infection from organisms colonizing the gastrointestinal tract. Evidence supporting this practice is lacking, however, and the actual efficacy of the ND remains unknown. Institutional policy at Northwestern Memorial Hospital discontinued the use of ND in 2006. We conducted a retrospective study of 726 consecutive HSCT recipients, 363 who received an ND and 363 who received a general hospital diet, to determine the incidence of microbiologically confirmed infections during and after transplantation. Our findings indicate a higher rate of infections in the HSCT recipients who received an ND.",

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AU - Helenowski, Irene

AU - Giel, Meghan

AU - Gobel, Barbara

AU - Pi, Judy

AU - Greenberg, Deborah

AU - Mehta, Jayesh

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AB - The use of a neutropenic diet (ND) after hematopoietic stem cell transplantation (HSCT) was instituted more than 30 years ago as a means of preventing infection from organisms colonizing the gastrointestinal tract. Evidence supporting this practice is lacking, however, and the actual efficacy of the ND remains unknown. Institutional policy at Northwestern Memorial Hospital discontinued the use of ND in 2006. We conducted a retrospective study of 726 consecutive HSCT recipients, 363 who received an ND and 363 who received a general hospital diet, to determine the incidence of microbiologically confirmed infections during and after transplantation. Our findings indicate a higher rate of infections in the HSCT recipients who received an ND.

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Questioning the Role of a Neutropenic Diet following Hematopoetic Stem Cell Transplantation

Abstract

Keywords

ASJC Scopus subject areas

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