R(+)-8-OH-DPAT, a 5-HT(1A) receptor agonist, inhibits amphetamine-induced serotonin and dopamine release in rat medial prefrontal cortex

Toshihide Kuroki*, Junji Ichikawa, Jin Dai, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Pretreatment with R(+)-8-OH-DPAT, a selective serotonin (5-HT)(1A) receptor agonist (50 μg/kg, s.c.), inhibited D-amphetamine sulfate (1.0 mg/kg, s.c.)-induced increases in extracellular levels of both 5-HT and dopamine (DA) in rat medial prefrontal cortex, as determined by in vivo microdialysis. The inhibitory effect of R(+)-8-OH-DPAT was completely reversed by the selective 5-HT(1A) receptor antagonist WAY 100,635 (100 μg/kg s.c.) administered 5 min prior to R(+)-8-OH-DPAT. These results suggest that stimulation of 5-HT(1A) receptors may inhibit amphetamine-induced release of 5-HT and DA in the medial prefrontal cortex.

Original languageEnglish (US)
Pages (from-to)357-361
Number of pages5
JournalBrain research
Volume743
Issue number1-2
DOIs
StatePublished - Dec 1 1996

Keywords

  • 5-HT(1A) receptor
  • D-amphetamine
  • R(+)-8-OH-DPAT
  • anxiety
  • dopamine
  • microdialysis
  • prefrontal cortex
  • rat
  • serotonin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'R(+)-8-OH-DPAT, a 5-HT(1A) receptor agonist, inhibits amphetamine-induced serotonin and dopamine release in rat medial prefrontal cortex'. Together they form a unique fingerprint.

  • Cite this