Abstract
Systemic administration of R(+)-8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), a selective serotonin (5-hydroxytryptamine, 5-HT)1A receptor agonist (25, 50, and 100 μg/kg s.c.), administered 30 min prior to d-amphetamine, significantly inhibited the d-amphetamine sulfate (1.0 mg/kg s.c.)-induced increase in extracellular dopamine levels in the striatum and nucleus accumbens of freely moving rats, as determined by in vivo microdialysis. The ability of R(+)-8-OH-DPAT (50 μg/kg s.c.) to inhibit d-amphetamine sulfate (1.0 mg/kg s.c.)-induced increase in extracellular dopamine levels was abolished by WAY 100,635 (n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl) cyclohexanecarboxamide trihydrochloride), a selective 5-HT1A receptor antagonist (100 μg/kg s.c.), administered 5 min prior to R(+)-8-OH-DPAT in both regions. These results indicate that the 5-HT1A receptor may exert an inhibitory effect on amphetamine-induced dopamine release.
Original language | English (US) |
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Pages (from-to) | 179-184 |
Number of pages | 6 |
Journal | European Journal of Pharmacology |
Volume | 287 |
Issue number | 2 |
DOIs | |
State | Published - Dec 12 1995 |
Keywords
- (Rat)
- 5-HT receptor
- Dopamine
- Microdialysis, in vivo
- Nucleus accumbens
- R(+)-8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin)
- Striatum
- WAY 100,635 (n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl)cyclohexanecarboxamide trihydrochloride)
- d-Amphetamine
ASJC Scopus subject areas
- Pharmacology