Abstract
R(+)-8-OH-DPAT (0.05, but not 0.025, 0.1, 1 mg/kg), a 5-HT(1A) receptor agonist, decreased l-3,4-dihydroxyphenylalanine (DOPA) accumulation in rat striatum following NSD-1015, an l-aromatic amino acid decarboxylase inhibitor. Amphetamine (1 mg/kg) increased striatal DOPA accumulation, an effect attenuated by R(+)-8-OH-DPAT (0.05 mg/kg). However, both amphetamine (1 mg/kg) and R(+)-8-OH-DPAT (0.05 mg/kg) decreased cortical DOPA accumulation; there were no additional decreases from their combination. Neither amphetamine (1 mg/kg), R(+)-8-OH-DPAT (0.05 mg/kg), or the combination, significantly affected DOPA accumulation in the nucleus accumbens. The significance of and possible mechanisms for these findings are discussed. (C) 2000 Elsevier Science B.V.
Original language | English (US) |
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Pages (from-to) | 204-207 |
Number of pages | 4 |
Journal | Brain research |
Volume | 872 |
Issue number | 1-2 |
DOIs | |
State | Published - Jul 28 2000 |
Keywords
- 5-HT(1A) receptor
- D-Amphetamine
- Dopamine synthesis
- R(+)-8-OH-DPAT
- Rat
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology