R(+)-8-OH-DPAT, a selective 5-HT(1A) receptor agonist, attenuated amphetamine-induced dopamine synthesis in rat striatum, but not nucleus accumbens or medial prefrontal cortex

Toshihide Kuroki, Jin Dai, Herbert Y. Meltzer, Junji Ichikawa*

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

R(+)-8-OH-DPAT (0.05, but not 0.025, 0.1, 1 mg/kg), a 5-HT(1A) receptor agonist, decreased l-3,4-dihydroxyphenylalanine (DOPA) accumulation in rat striatum following NSD-1015, an l-aromatic amino acid decarboxylase inhibitor. Amphetamine (1 mg/kg) increased striatal DOPA accumulation, an effect attenuated by R(+)-8-OH-DPAT (0.05 mg/kg). However, both amphetamine (1 mg/kg) and R(+)-8-OH-DPAT (0.05 mg/kg) decreased cortical DOPA accumulation; there were no additional decreases from their combination. Neither amphetamine (1 mg/kg), R(+)-8-OH-DPAT (0.05 mg/kg), or the combination, significantly affected DOPA accumulation in the nucleus accumbens. The significance of and possible mechanisms for these findings are discussed. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)204-207
Number of pages4
JournalBrain Research
Volume872
Issue number1-2
DOIs
StatePublished - Jul 28 2000

Keywords

  • 5-HT(1A) receptor
  • D-Amphetamine
  • Dopamine synthesis
  • R(+)-8-OH-DPAT
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

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