Rabbit-specific ventricular model of cardiac electrophysiological function including specialized conduction system

R. Bordas, K. Gillow, Q. Lou, I. R. Efimov, D. Gavaghan, P. Kohl, V. Grau, B. Rodriguez*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations

Abstract

The function of the ventricular specialized conduction system in the heart is to ensure the coordinated electrical activation of the ventricles. It is therefore critical to the overall function of the heart, and has also been implicated as an important player in various diseases, including lethal ventricular arrhythmias such as ventricular fibrillation and drug-induced torsades de pointes. However, current ventricular models of electrophysiology usually ignore, or include highly simplified representations of the specialized conduction system. Here, we describe the development of an image-based, species-consistent, anatomically-detailed model of rabbit ventricular electrophysiology that incorporates a detailed description of the free-running part of the specialized conduction system. Techniques used for the construction of the geometrical model of the specialized conduction system from a magnetic resonance dataset and integration of the system model into a ventricular anatomical model, developed from the same dataset, are described. Computer simulations of rabbit ventricular electrophysiology are conducted using the novel anatomical model and rabbit-specific membrane kinetics to investigate the importance of the components and properties of the conduction system in determining ventricular function under physiological conditions. Simulation results are compared to panoramic optical mapping experiments for model validation and results interpretation. Full access is provided to the anatomical models developed in this study.

Original languageEnglish (US)
Pages (from-to)90-100
Number of pages11
JournalProgress in Biophysics and Molecular Biology
Volume107
Issue number1
DOIs
StatePublished - Oct 2011
Externally publishedYes

Keywords

  • Activation sequence
  • Electrophysiology simulation
  • His-Purkinje system

ASJC Scopus subject areas

  • Biophysics
  • Molecular Biology

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