Rabbit VX2 Tumors as an Animal Model of Uterine Fibroids and for Uterine Artery Embolization

Thomas K. Rhee; Robert K. Ryu; Affaan K. Bangash; Dingxin Wang; Barbara Szolc-Kowalska; Kathleen R. Harris; Kent T. Sato; Howard B. Chrisman; Robert L. Vogelzang; Tatjana Paunesku; Gayle E. Woloschak; Andrew C. Larson; Reed A. Omary

doi:10.1016/j.jvir.2007.01.013

Rabbit VX2 Tumors as an Animal Model of Uterine Fibroids and for Uterine Artery Embolization

Thomas K. Rhee, Robert K. Ryu^*, Affaan K. Bangash, Dingxin Wang, Barbara Szolc-Kowalska, Kathleen R. Harris, Kent T. Sato, Howard B. Chrisman, Robert L. Vogelzang, Tatjana Paunesku, Gayle E. Woloschak, Andrew C. Larson, Reed A. Omary

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Purpose: To determine the suitability of the rabbit VX2 tumor animal model for uterine fibroids and uterine artery embolization (UAE). Materials and Methods: The authors implanted and grew one uterine VX2 tumor per rabbit in six rabbits. UAE was performed by using 100-300 μm embolic particles and confirmed with x-ray digital subtraction angiography, magnetic resonance (MR) imaging, and necropsy. Unenhanced and contrast medium-enhanced MR images of VX2 tumors were obtained before and after UAE. Relative MR signal-to noise-ratio (SNR) was measured in the uterine VX2 tumor and in normal uterine tissue before and after UAE and compared by using a paired t-test (P = .05). Results: VX2 uterine tumors were successfully grown, and both VX2 tumor presence in the uterus and UAE were seen angiographically and confirmed with necropsy in all six rabbits. Statistically significant reductions in relative SNRs were measured in tumors (SNR before UAE, 15.3 ± 5.15; SNR after UAE, 3.84 ± 3.94; P < .0001). No statistically significant decrease in SNR was measured in normal uterine tissue before and after UAE (P = .63 for the right uterine horn and P = .93 for the left uterine horn). Conclusion: Rabbit VX2 uterine tumors may be a suitable animal model of uterine fibroids and UAE.

Original language	English (US)
Pages (from-to)	411-418
Number of pages	8
Journal	Journal of Vascular and Interventional Radiology
Volume	18
Issue number	3
DOIs	https://doi.org/10.1016/j.jvir.2007.01.013
State	Published - Mar 2007

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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Rhee, T. K., Ryu, R. K., Bangash, A. K., Wang, D., Szolc-Kowalska, B., Harris, K. R., Sato, K. T., Chrisman, H. B., Vogelzang, R. L., Paunesku, T., Woloschak, G. E., Larson, A. C., & Omary, R. A. (2007). Rabbit VX2 Tumors as an Animal Model of Uterine Fibroids and for Uterine Artery Embolization. Journal of Vascular and Interventional Radiology, 18(3), 411-418. https://doi.org/10.1016/j.jvir.2007.01.013

@article{9a5515a562ee4f04b30cea1502c36d99,

title = "Rabbit VX2 Tumors as an Animal Model of Uterine Fibroids and for Uterine Artery Embolization",

abstract = "Purpose: To determine the suitability of the rabbit VX2 tumor animal model for uterine fibroids and uterine artery embolization (UAE). Materials and Methods: The authors implanted and grew one uterine VX2 tumor per rabbit in six rabbits. UAE was performed by using 100-300 μm embolic particles and confirmed with x-ray digital subtraction angiography, magnetic resonance (MR) imaging, and necropsy. Unenhanced and contrast medium-enhanced MR images of VX2 tumors were obtained before and after UAE. Relative MR signal-to noise-ratio (SNR) was measured in the uterine VX2 tumor and in normal uterine tissue before and after UAE and compared by using a paired t-test (P = .05). Results: VX2 uterine tumors were successfully grown, and both VX2 tumor presence in the uterus and UAE were seen angiographically and confirmed with necropsy in all six rabbits. Statistically significant reductions in relative SNRs were measured in tumors (SNR before UAE, 15.3 ± 5.15; SNR after UAE, 3.84 ± 3.94; P < .0001). No statistically significant decrease in SNR was measured in normal uterine tissue before and after UAE (P = .63 for the right uterine horn and P = .93 for the left uterine horn). Conclusion: Rabbit VX2 uterine tumors may be a suitable animal model of uterine fibroids and UAE.",

author = "Rhee, {Thomas K.} and Ryu, {Robert K.} and Bangash, {Affaan K.} and Dingxin Wang and Barbara Szolc-Kowalska and Harris, {Kathleen R.} and Sato, {Kent T.} and Chrisman, {Howard B.} and Vogelzang, {Robert L.} and Tatjana Paunesku and Woloschak, {Gayle E.} and Larson, {Andrew C.} and Omary, {Reed A.}",

note = "Funding Information: None of the authors has identified a conflict of interest. R.A.O. was supported in part by National Institutes of Health grant K08 DK60020. T.P. and G.E.W. were supported in part by National Institutes of Health grants CA81375, CA73042, and NS 21442. Supported in part by an unrestricted gift from Terumo, Inc. Contents of this manuscript were presented at 2006 SIR 31 st Annual Scientific Meeting. ",

year = "2007",

month = mar,

doi = "10.1016/j.jvir.2007.01.013",

language = "English (US)",

volume = "18",

pages = "411--418",

journal = "Journal of Vascular and Interventional Radiology",

issn = "1051-0443",

publisher = "Elsevier Inc.",

number = "3",

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Rhee, TK, Ryu, RK, Bangash, AK, Wang, D, Szolc-Kowalska, B, Harris, KR, Sato, KT , Chrisman, HB , Vogelzang, RL , Paunesku, T , Woloschak, GE, Larson, AC & Omary, RA 2007, 'Rabbit VX2 Tumors as an Animal Model of Uterine Fibroids and for Uterine Artery Embolization', Journal of Vascular and Interventional Radiology, vol. 18, no. 3, pp. 411-418. https://doi.org/10.1016/j.jvir.2007.01.013

TY - JOUR

T1 - Rabbit VX2 Tumors as an Animal Model of Uterine Fibroids and for Uterine Artery Embolization

AU - Rhee, Thomas K.

AU - Ryu, Robert K.

AU - Bangash, Affaan K.

AU - Wang, Dingxin

AU - Szolc-Kowalska, Barbara

AU - Harris, Kathleen R.

AU - Sato, Kent T.

AU - Chrisman, Howard B.

AU - Vogelzang, Robert L.

AU - Paunesku, Tatjana

AU - Woloschak, Gayle E.

AU - Larson, Andrew C.

AU - Omary, Reed A.

N1 - Funding Information: None of the authors has identified a conflict of interest. R.A.O. was supported in part by National Institutes of Health grant K08 DK60020. T.P. and G.E.W. were supported in part by National Institutes of Health grants CA81375, CA73042, and NS 21442. Supported in part by an unrestricted gift from Terumo, Inc. Contents of this manuscript were presented at 2006 SIR 31 st Annual Scientific Meeting.

PY - 2007/3

Y1 - 2007/3

N2 - Purpose: To determine the suitability of the rabbit VX2 tumor animal model for uterine fibroids and uterine artery embolization (UAE). Materials and Methods: The authors implanted and grew one uterine VX2 tumor per rabbit in six rabbits. UAE was performed by using 100-300 μm embolic particles and confirmed with x-ray digital subtraction angiography, magnetic resonance (MR) imaging, and necropsy. Unenhanced and contrast medium-enhanced MR images of VX2 tumors were obtained before and after UAE. Relative MR signal-to noise-ratio (SNR) was measured in the uterine VX2 tumor and in normal uterine tissue before and after UAE and compared by using a paired t-test (P = .05). Results: VX2 uterine tumors were successfully grown, and both VX2 tumor presence in the uterus and UAE were seen angiographically and confirmed with necropsy in all six rabbits. Statistically significant reductions in relative SNRs were measured in tumors (SNR before UAE, 15.3 ± 5.15; SNR after UAE, 3.84 ± 3.94; P < .0001). No statistically significant decrease in SNR was measured in normal uterine tissue before and after UAE (P = .63 for the right uterine horn and P = .93 for the left uterine horn). Conclusion: Rabbit VX2 uterine tumors may be a suitable animal model of uterine fibroids and UAE.

AB - Purpose: To determine the suitability of the rabbit VX2 tumor animal model for uterine fibroids and uterine artery embolization (UAE). Materials and Methods: The authors implanted and grew one uterine VX2 tumor per rabbit in six rabbits. UAE was performed by using 100-300 μm embolic particles and confirmed with x-ray digital subtraction angiography, magnetic resonance (MR) imaging, and necropsy. Unenhanced and contrast medium-enhanced MR images of VX2 tumors were obtained before and after UAE. Relative MR signal-to noise-ratio (SNR) was measured in the uterine VX2 tumor and in normal uterine tissue before and after UAE and compared by using a paired t-test (P = .05). Results: VX2 uterine tumors were successfully grown, and both VX2 tumor presence in the uterus and UAE were seen angiographically and confirmed with necropsy in all six rabbits. Statistically significant reductions in relative SNRs were measured in tumors (SNR before UAE, 15.3 ± 5.15; SNR after UAE, 3.84 ± 3.94; P < .0001). No statistically significant decrease in SNR was measured in normal uterine tissue before and after UAE (P = .63 for the right uterine horn and P = .93 for the left uterine horn). Conclusion: Rabbit VX2 uterine tumors may be a suitable animal model of uterine fibroids and UAE.

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JO - Journal of Vascular and Interventional Radiology

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Rabbit VX2 Tumors as an Animal Model of Uterine Fibroids and for Uterine Artery Embolization

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