Racial differences in bone mineral density and fractures in men receiving androgen deprivation therapy for prostate cancer

Alicia K. Morgans*, Michael L. Hancock, K. Gary Barnette, Mitchell S. Steiner, Ronald A. Morton, Matthew R. Smith

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Purpose: Whether race influences bone loss and fracture risk during androgen deprivation therapy for prostate cancer is unknown. Using data from a prospective clinical trial we compared bone mineral density and fracture between African-American and Caucasian men receiving androgen deprivation therapy. Materials and Methods: A total of 516 subjects were in the placebo group of a 2-year randomized placebo controlled fracture prevention trial, and were African-American (68) or Caucasian (448). We compared baseline characteristics, changes in bone mineral density and rates of new fractures between races. Results: Compared to Caucasian men, African-American men had higher baseline hip bone mineral density (mean ± SD 0.98 ± 0.15 vs 0.91 ± 0.15 gm/m 2, p = 0.001) and similar spine bone mineral density (1.09 ± 0.22 vs 1.11 ± 0.22, p = 0.51). There was no difference in prevalent vertebral fractures between African-American and Caucasian men (7.4% vs 15.0%, p = 0.13). The percentage change in hip bone mineral density at 2 years was similar between African-American and Caucasian men (mean ± SE -2.21% ± 0.59% vs -2.54% ± 0.26%, p = 0.65). Changes in bone mineral density of the lumbar spine were also similar between African-American and Caucasian men (-1.74% ± 0.69% vs -1.30% ± 0.33%, p = 0.64). No new vertebral fractures were reported in African-American men but 2 fractures were reported in Caucasian men. Conclusions: In a clinical trial African-American men receiving androgen deprivation therapy for prostate cancer have a greater hip bone mineral density and tended to have fewer prevalent vertebral fractures than Caucasian men. Despite a lower baseline risk of osteoporosis and fracture, African-American men experience a decrease in bone mineral density similar to that of Caucasian men.

Original languageEnglish (US)
Pages (from-to)889-893
Number of pages5
JournalJournal of Urology
Volume187
Issue number3
DOIs
StatePublished - Mar 1 2012

Keywords

  • androgens
  • bone
  • bone density
  • fractures
  • prostatic neoplasms
  • survival rate

ASJC Scopus subject areas

  • Urology

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