@article{a5fb834acb4347a29ac7fd0e52e37a93,
title = "Racial differences in weathering and its associations with psychosocial stress: The CARDIA study",
abstract = "Biological age (BA) is a construct that captures accelerated biological aging attributable to “wear and tear” from various exposures; we measured BA and weathering, defined as the difference between BA and chronological age, and their associations with race and psychosocial factors in a middle-aged bi-racial cohort. We used data from the Coronary Artery Risk in Young Adults study (CARDIA), conducted in 4 U.S. cities from 1985–2016 to examine weathering for adults aged 48–60 years. We estimated BA via the Klemera and Doubal method using selected biomarkers. We assessed overall and race-specific associations between weathering and psychosocial measures. For the 2694 participants included, Blacks had a BA (SD) that was 2.6 (11.8) years older than their chronological age while the average BA among Whites was 3.5 (10.0) years younger than their chronological age (Blacks weathered 6.1 years faster than Whites). Belonging to more social groups was associated with less weathering in Blacks but not Whites, and after multivariable adjustment, lower SES and more depressive symptoms were associated with more weathering among Blacks than among Whites. We confirmed racial differences in weathering, and newly documented that similar psychosocial factors may take a greater toll on the biological health of Blacks than Whites.",
keywords = "Biological age, Psychosocial factors racial disparity, Weathering",
author = "Sarah Forrester and David Jacobs and Rachel Zmora and Pamela Schreiner and Veronique Roger and Kiefe, {Catarina I.}",
note = "Funding Information: The Coronary Artery Risk Development in Young Adults Study (CARDIA) is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham (HHSN268201300025C & HHSN268201300026C), Northwestern University (HHSN268201300027C), University of Minnesota (HHSN268201300028C), Kaiser Foundation Research Institute (HHSN268201300029C), and Johns Hopkins University School of Medicine (HHSN268200900041C). CARDIA is also partially supported by the Intramural Research Program of the National Institute on Aging (NIA) and an intra-agency agreement between NIA and NHLBI (AG0005). This manuscript has been reviewed by CARDIA for scientific content. Funding Information: Dr. Forrester was supported by Department of Health and Human Services grant 5TL1TR001454 during conception, analysis, and completion of the manuscript. Funding Information: The Coronary Artery Risk Development in Young Adults Study (CARDIA) is conducted and supported by the National Heart, Lung, and Blood Institute ( NHLBI ) in collaboration with the University of Alabama at Birmingham ( HHSN268201300025C & HHSN268201300026C ), Northwestern University ( HHSN268201300027C ), University of Minnesota ( HHSN268201300028C ), Kaiser Foundation Research Institute ( HHSN268201300029C ), and Johns Hopkins University School of Medicine ( HHSN268200900041C ). CARDIA is also partially supported by the Intramural Research Program of the National Institute on Aging ( NIA ) and an intra-agency agreement between NIA and NHLBI (AG0005). This manuscript has been reviewed by CARDIA for scientific content. Publisher Copyright: {\textcopyright} 2018 The Authors",
year = "2019",
month = apr,
doi = "10.1016/j.ssmph.2018.11.003",
language = "English (US)",
volume = "7",
journal = "SSM - Population Health",
issn = "2352-8273",
publisher = "Elsevier Limited",
}
