@article{60c07519e147497689304b18307324a9,
title = "Racial/ethnic differences in left ventricular structure and function in chronic kidney disease: The chronic renal insufficiency cohort",
abstract = "BACKGROUND Chronic kidney disease (CKD) is associated with increased risk of cardiovascular disease (CVD) and it is especially common among Blacks. Left ventricular hypertrophy (LVH) is an important subclinical marker of CVD, but there are limited data on racial variation in left ventricular structure and function among persons with CKD. METHODS In a cross-sectional analysis of the Chronic Renal Insufficiency Cohort Study, we compared the prevalence of different types of left ventricular remodeling (concentric hypertrophy, eccentric hypertrophy, and concentric remodeling) by race/ethnicity. We used multinomial logistic regression to test whether race/ethnicity associated with different types of left ventricular remodeling independently of potential confounding factors. RESULTS We identified 1,164 non-Hispanic Black and 1,155 non-Hispanic White participants who completed Year 1 visits with echocardiograms that had sufficient data to categorize left ventricular geometry type. Compared to non-Hispanic Whites, non-Hispanic Blacks had higher mean left ventricular mass index (54.7 ± 14.6 vs. 47.4 ± 12.2 g/m2.7; P < 0.0001) and prevalence of concentric LVH (45.8% vs. 24.9%). In addition to higher systolic blood pressure and treatment with >3 antihypertensive medications, Black race/ethnicity was independently associated with higher odds of concentric LVH compared to White race/ethnicity (odds ratio: 2.73; 95% confidence interval: 2.02, 3.69). CONCLUSION In a large, diverse cohort with CKD, we found significant differences in left ventricular mass and hypertrophic morphology between non- Hispanic Blacks and Whites. Future studies will evaluate whether higher prevalence of LVH contribute to racial/ethnic disparities in cardiovascular outcomes among CKD patients.",
keywords = "Blood pressure, Echocardiography, Hypertension, Left ventricular hypertrophy, Race and ethnicity, Remodeling, Renal insufficiency",
author = "Ahmad, {Faraz S.} and Xuan Cai and Katherine Kunkel and Ricardo, {Ana C.} and Lash, {James P.} and Raj, {Dominic S.} and Jiang He and Anderson, {Amanda H.} and Budoff, {Matthew J.} and Nunes, {Julie A.Wright} and Jason Roy and Wright, {Jackson T.} and Go, {Alan S.} and Sutton, {Martin G.St John} and Kusek, {John W.} and Tamara Isakova and Myles Wolf and Keane, {Martin G.} and Appel, {Lawrence J.} and Feldman, {Harold I.} and Akinlolu Ojo and Mahboob Rahman and Townsend, {Raymond R.}",
note = "Funding Information: the CRIC Study was obtained under a cooperative agreement from the US National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK; U01DK060990, U01DK060984, U01DK061022, U01DK0 61021, U01DK061028, U01DK060980, U01DK060963, and U01DK060902). In addition, this work was supported in part by the Perelman School of Medicine at the University of Pennsylvania Clinical and Translational Science Award National Institutes of Health (NIH)/National Center for Advancing Translational Sciences UL1TR000003, Johns Hopkins University UL1 TR-000424, University of Maryland General Clinic Research Center M01 RR-16500, Clinical and Translational Science Collaborative of Cleveland, UL1TR000439 from the National Center for Advancing Translational Sciences (NCATS) component of the NIH and NIH roadmap for Medical Research, Michigan Institute for Clinical and Health Research UL1TR000433, University of Illinois at Chicago Clinical and Translational Science Award UL1RR029879, Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases P20 GM109036, Kaiser Permanente Northern California NIH/ National Center for Research Resources University of California San Francisco Clinical and Translational Science Institute UL1 RR-024131. Dr Ahmad was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under Award number T32HL069771 and by a Research Fellowship Award from the Heart Failure Society of America. Dr Ricardo was supported by The National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under Award number K23DK094829. For this work, Dr Wolf was supported by grants R01DK076116, R01DK081374, and K24DK093723, from the National Institutes of Health, and a Strategically Focused Research Network Center Grant on Health Disparities from the American Heart Association. Dr Wright Nunes was support by The National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under Award number K23DK097183. Publisher Copyright: {\textcopyright} American Journal of Hypertension, Ltd 2017.",
year = "2017",
month = aug,
day = "1",
doi = "10.1093/ajh/hpx058",
language = "English (US)",
volume = "30",
pages = "822--829",
journal = "American Journal of Hypertension",
issn = "0895-7061",
number = "8",
}
