Radiant energy required for infrared neural stimulation

Xiaodong Tan, Suhrud Rajguru, Hunter Young, Nan Xia, Stuart R Stock, Xianghui Xiao, Claus-Peter Richter*

*Corresponding author for this work

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Infrared neural stimulation (INS) has been proposed as an alternative method to electrical stimulation because of its spatial selective stimulation. Independent of the mechanism for INS, to translate the method into a device it is important to determine the energy for stimulation required at the target structure. Custom-designed, flat and angle polished fibers, were used to deliver the photons. By rotating the angle polished fibers, the orientation of the radiation beam in the cochlea could be changed. INS-evoked compound action potentials and single unit responses in the central nucleus of the inferior colliculus (ICC) were recorded. X-ray computed tomography was used to determine the orientation of the optical fiber. Maximum responses were observed when the radiation beam was directed towards the spiral ganglion neurons (SGNs), whereas little responses were seen when the beam was directed towards the basilar membrane. The radiant exposure required at the SGNs to evoke compound action potentials (CAPs) or ICC responses was on average 18.9±12.2 or 10.3±4.9mJ/cm 2, respectively. For cochlear INS it has been debated whether the radiation directly stimulates the SGNs or evokes a photoacoustic effect. The results support the view that a direct interaction between neurons and radiation dominates the response to INS.

Original languageEnglish (US)
Article number13273
JournalScientific Reports
Volume5
DOIs
StatePublished - Aug 25 2015

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Spiral Ganglion
Radiation
Neurons
Inferior Colliculi
Cochlea
Action Potentials
Basilar Membrane
Optical Fibers
X Ray Computed Tomography
Photons
Electric Stimulation
Equipment and Supplies

ASJC Scopus subject areas

  • General

Cite this

Tan, Xiaodong ; Rajguru, Suhrud ; Young, Hunter ; Xia, Nan ; Stock, Stuart R ; Xiao, Xianghui ; Richter, Claus-Peter. / Radiant energy required for infrared neural stimulation. In: Scientific Reports. 2015 ; Vol. 5.
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Radiant energy required for infrared neural stimulation. / Tan, Xiaodong; Rajguru, Suhrud; Young, Hunter; Xia, Nan; Stock, Stuart R; Xiao, Xianghui; Richter, Claus-Peter.

In: Scientific Reports, Vol. 5, 13273, 25.08.2015.

Research output: Contribution to journalArticle

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Tan X, Rajguru S, Young H, Xia N, Stock SR, Xiao X et al. Radiant energy required for infrared neural stimulation. Scientific Reports. 2015 Aug 25;5. 13273. https://doi.org/10.1038/srep13273