Radiation-Associated Cardiac Disease: A Practical Approach to Diagnosis and Management

Milind Y. Desai*, Christine L. Jellis, Rupesh Kotecha, Douglas R. Johnston, Brian P. Griffin

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

99 Scopus citations


Radiation-associated cardiac disease (RACD) results in complex clinical presentations, unique management issues, and increased morbidity and mortality. Patients typically present years or even decades after radiation exposure, with delayed-onset cardiac damage sustained from high cumulative doses. Multimodality imaging is crucial to determine the manifestations and severity of disease because symptoms are often nonspecific. Comprehensive screening using a coordinated approach may enable early detection. However, timing of intervention should be carefully considered in these patients because surgery is often complex and high-risk second surgeries should be minimized in the long-term. This review aims to provide treating physicians with a comprehensive and clinically focused overview of RACD, including clinical/imaging manifestations, multi-modality screening recommendations, and management options.

Original languageEnglish (US)
Pages (from-to)1132-1149
Number of pages18
JournalJACC: Cardiovascular Imaging
Issue number8
StatePublished - Aug 2018


  • diagnosis
  • management
  • radiation heart disease
  • review

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging


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