TY - JOUR
T1 - Radiation dose rate effects
T2 - what is new and what is needed?
AU - Lowe, Donna
AU - Roy, Laurence
AU - Tabocchini, Maria Antonella
AU - Rühm, Werner
AU - Wakeford, Richard
AU - Woloschak, Gayle E.
AU - Laurier, Dominique
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/11
Y1 - 2022/11
N2 - Despite decades of research to understand the biological effects of ionising radiation, there is still much uncertainty over the role of dose rate. Motivated by a virtual workshop on the “Effects of spatial and temporal variation in dose delivery” organised in November 2020 by the Multidisciplinary Low Dose Initiative (MELODI), here, we review studies to date exploring dose rate effects, highlighting significant findings, recent advances and to provide perspective and recommendations for requirements and direction of future work. A comprehensive range of studies is considered, including molecular, cellular, animal, and human studies, with a focus on low linear-energy-transfer radiation exposure. Limits and advantages of each type of study are discussed, and a focus is made on future research needs.
AB - Despite decades of research to understand the biological effects of ionising radiation, there is still much uncertainty over the role of dose rate. Motivated by a virtual workshop on the “Effects of spatial and temporal variation in dose delivery” organised in November 2020 by the Multidisciplinary Low Dose Initiative (MELODI), here, we review studies to date exploring dose rate effects, highlighting significant findings, recent advances and to provide perspective and recommendations for requirements and direction of future work. A comprehensive range of studies is considered, including molecular, cellular, animal, and human studies, with a focus on low linear-energy-transfer radiation exposure. Limits and advantages of each type of study are discussed, and a focus is made on future research needs.
KW - Dose rate
KW - Epidemiology
KW - Ionising radiation
KW - Low-LET
KW - Radiobiology
KW - Recommendations
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U2 - 10.1007/s00411-022-00996-0
DO - 10.1007/s00411-022-00996-0
M3 - Article
C2 - 36241855
AN - SCOPUS:85140085662
SN - 0301-634X
VL - 61
SP - 507
EP - 543
JO - Radiation and Environmental Biophysics
JF - Radiation and Environmental Biophysics
IS - 4
ER -