Radiation dose rate effects: what is new and what is needed?

Donna Lowe, Laurence Roy, Maria Antonella Tabocchini, Werner Rühm, Richard Wakeford, Gayle E. Woloschak*, Dominique Laurier

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Despite decades of research to understand the biological effects of ionising radiation, there is still much uncertainty over the role of dose rate. Motivated by a virtual workshop on the “Effects of spatial and temporal variation in dose delivery” organised in November 2020 by the Multidisciplinary Low Dose Initiative (MELODI), here, we review studies to date exploring dose rate effects, highlighting significant findings, recent advances and to provide perspective and recommendations for requirements and direction of future work. A comprehensive range of studies is considered, including molecular, cellular, animal, and human studies, with a focus on low linear-energy-transfer radiation exposure. Limits and advantages of each type of study are discussed, and a focus is made on future research needs.

Original languageEnglish (US)
Pages (from-to)507-543
Number of pages37
JournalRadiation and Environmental Biophysics
Volume61
Issue number4
DOIs
StatePublished - Nov 2022

Keywords

  • Dose rate
  • Epidemiology
  • Ionising radiation
  • Low-LET
  • Radiobiology
  • Recommendations

ASJC Scopus subject areas

  • General Environmental Science
  • Radiation
  • Biophysics

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