@article{17ece6b8a0b64f06b9626ee68702aea4,
title = "Radiation dose rate effects: what is new and what is needed?",
abstract = "Despite decades of research to understand the biological effects of ionising radiation, there is still much uncertainty over the role of dose rate. Motivated by a virtual workshop on the “Effects of spatial and temporal variation in dose delivery” organised in November 2020 by the Multidisciplinary Low Dose Initiative (MELODI), here, we review studies to date exploring dose rate effects, highlighting significant findings, recent advances and to provide perspective and recommendations for requirements and direction of future work. A comprehensive range of studies is considered, including molecular, cellular, animal, and human studies, with a focus on low linear-energy-transfer radiation exposure. Limits and advantages of each type of study are discussed, and a focus is made on future research needs.",
keywords = "Dose rate, Epidemiology, Ionising radiation, Low-LET, Radiobiology, Recommendations",
author = "Donna Lowe and Laurence Roy and Tabocchini, {Maria Antonella} and Werner R{\"u}hm and Richard Wakeford and Woloschak, {Gayle E.} and Dominique Laurier",
note = "Funding Information: The authors would like to thank the MELODI platform for the opportunity to prepare this review and Bal{\'a}zs Madas for coordination of multithemed reviews. We would also like to thank Magali Edouard and Serge Dreuil from IRSN for their invaluable expertise on dose rates in medical practise. DLowe would like to thank UK Health Security Agency for funding and Simon Bouffler for Departmental support. Funding Information: The authors would like to thank the MELODI platform for the opportunity to prepare this review and Bal{\'a}zs Madas for coordination of multithemed reviews. We would also like to thank Magali Edouard and Serge Dreuil from IRSN for their invaluable expertise on dose rates in medical practise. DLowe would like to thank UK Health Security Agency for funding and Simon Bouffler for Departmental support. Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = nov,
doi = "10.1007/s00411-022-00996-0",
language = "English (US)",
volume = "61",
pages = "507--543",
journal = "Biophysik",
issn = "0301-634X",
publisher = "Springer New York",
number = "4",
}