Abstract
Surgical resection has long been considered curative for patients with early-stage hepatocellular carcinoma (HCC). However, inadequate future liver remnant (FLR) renders many patients not amenable to surgery. Recently, lobar administration of yttrium-90 (Y90) radioembolization has been utilized to induce FLR hypertrophy while providing disease control, eventually facilitating resection in patients with hepatic malignancy. This has been termed radiation lobectomy (RL). The concept is evolving, with modified approaches combining RL and high-dose curative-intent radioembolization (radiation segmentectomy) to achieve tumor ablation. This article provides an overview of the concept and applications of RL, including technical considerations and outcomes in patients with hepatic malignancies.
Original language | English (US) |
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Pages (from-to) | 419-424 |
Number of pages | 6 |
Journal | Seminars in Interventional Radiology |
Volume | 38 |
Issue number | 4 |
DOIs | |
State | Published - Oct 1 2021 |
Funding
R.S. is a consultant to Boston Scientific and Sirtex. R.J.L. is a consultant to Boston Scientific and receives a research grant from National Cancer Institute (1R01CA233878–02).
Keywords
- future liver remnant
- hepatocellular carcinoma
- interventional radiology
- radiation lobectomy
- radioembolization
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine