Radiation Lobectomy: An Overview of Concept and Applications, Technical Considerations, Outcomes

Pouya Entezari, Ahmed Gabr, Kristie Kennedy, Riad Salem, Robert J. Lewandowski*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Surgical resection has long been considered curative for patients with early-stage hepatocellular carcinoma (HCC). However, inadequate future liver remnant (FLR) renders many patients not amenable to surgery. Recently, lobar administration of yttrium-90 (Y90) radioembolization has been utilized to induce FLR hypertrophy while providing disease control, eventually facilitating resection in patients with hepatic malignancy. This has been termed radiation lobectomy (RL). The concept is evolving, with modified approaches combining RL and high-dose curative-intent radioembolization (radiation segmentectomy) to achieve tumor ablation. This article provides an overview of the concept and applications of RL, including technical considerations and outcomes in patients with hepatic malignancies.

Original languageEnglish (US)
Pages (from-to)419-424
Number of pages6
JournalSeminars in Interventional Radiology
Volume38
Issue number4
DOIs
StatePublished - Oct 1 2021

Keywords

  • future liver remnant
  • hepatocellular carcinoma
  • interventional radiology
  • radiation lobectomy
  • radioembolization

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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