Radiation Lobectomy: An Overview of Concept and Applications, Technical Considerations, Outcomes

Pouya Entezari; Ahmed Gabr; Kristie Kennedy; Riad Salem; Robert J. Lewandowski

doi:10.1055/s-0041-1735530

Radiation Lobectomy: An Overview of Concept and Applications, Technical Considerations, Outcomes

Pouya Entezari, Ahmed Gabr, Kristie Kennedy, Riad Salem, Robert J. Lewandowski^*

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

Surgical resection has long been considered curative for patients with early-stage hepatocellular carcinoma (HCC). However, inadequate future liver remnant (FLR) renders many patients not amenable to surgery. Recently, lobar administration of yttrium-90 (Y90) radioembolization has been utilized to induce FLR hypertrophy while providing disease control, eventually facilitating resection in patients with hepatic malignancy. This has been termed radiation lobectomy (RL). The concept is evolving, with modified approaches combining RL and high-dose curative-intent radioembolization (radiation segmentectomy) to achieve tumor ablation. This article provides an overview of the concept and applications of RL, including technical considerations and outcomes in patients with hepatic malignancies.

Original language	English (US)
Pages (from-to)	419-424
Number of pages	6
Journal	Seminars in Interventional Radiology
Volume	38
Issue number	4
DOIs	https://doi.org/10.1055/s-0041-1735530
State	Published - Oct 1 2021

Funding

R.S. is a consultant to Boston Scientific and Sirtex. R.J.L. is a consultant to Boston Scientific and receives a research grant from National Cancer Institute (1R01CA233878–02).

Keywords

future liver remnant
hepatocellular carcinoma
interventional radiology
radiation lobectomy
radioembolization

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1055/s-0041-1735530

Cite this

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title = "Radiation Lobectomy: An Overview of Concept and Applications, Technical Considerations, Outcomes",

abstract = "Surgical resection has long been considered curative for patients with early-stage hepatocellular carcinoma (HCC). However, inadequate future liver remnant (FLR) renders many patients not amenable to surgery. Recently, lobar administration of yttrium-90 (Y90) radioembolization has been utilized to induce FLR hypertrophy while providing disease control, eventually facilitating resection in patients with hepatic malignancy. This has been termed radiation lobectomy (RL). The concept is evolving, with modified approaches combining RL and high-dose curative-intent radioembolization (radiation segmentectomy) to achieve tumor ablation. This article provides an overview of the concept and applications of RL, including technical considerations and outcomes in patients with hepatic malignancies.",

keywords = "future liver remnant, hepatocellular carcinoma, interventional radiology, radiation lobectomy, radioembolization",

author = "Pouya Entezari and Ahmed Gabr and Kristie Kennedy and Riad Salem and Lewandowski, {Robert J.}",

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AU - Entezari, Pouya

AU - Gabr, Ahmed

AU - Kennedy, Kristie

AU - Salem, Riad

AU - Lewandowski, Robert J.

N1 - Funding Information: R.S. is a consultant to Boston Scientific and Sirtex. R.J.L. is a consultant to Boston Scientific and receives a research grant from National Cancer Institute (1R01CA233878–02). Publisher Copyright: © 2021 Thieme Medical Publishers, Inc.. All rights reserved.

PY - 2021/10/1

Y1 - 2021/10/1

N2 - Surgical resection has long been considered curative for patients with early-stage hepatocellular carcinoma (HCC). However, inadequate future liver remnant (FLR) renders many patients not amenable to surgery. Recently, lobar administration of yttrium-90 (Y90) radioembolization has been utilized to induce FLR hypertrophy while providing disease control, eventually facilitating resection in patients with hepatic malignancy. This has been termed radiation lobectomy (RL). The concept is evolving, with modified approaches combining RL and high-dose curative-intent radioembolization (radiation segmentectomy) to achieve tumor ablation. This article provides an overview of the concept and applications of RL, including technical considerations and outcomes in patients with hepatic malignancies.

AB - Surgical resection has long been considered curative for patients with early-stage hepatocellular carcinoma (HCC). However, inadequate future liver remnant (FLR) renders many patients not amenable to surgery. Recently, lobar administration of yttrium-90 (Y90) radioembolization has been utilized to induce FLR hypertrophy while providing disease control, eventually facilitating resection in patients with hepatic malignancy. This has been termed radiation lobectomy (RL). The concept is evolving, with modified approaches combining RL and high-dose curative-intent radioembolization (radiation segmentectomy) to achieve tumor ablation. This article provides an overview of the concept and applications of RL, including technical considerations and outcomes in patients with hepatic malignancies.

KW - future liver remnant

KW - hepatocellular carcinoma

KW - interventional radiology

KW - radiation lobectomy

KW - radioembolization

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SN - 0739-9529

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ER -

Radiation Lobectomy: An Overview of Concept and Applications, Technical Considerations, Outcomes

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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