TY - JOUR
T1 - Radiation Lobectomy
T2 - An Overview of Concept and Applications, Technical Considerations, Outcomes
AU - Entezari, Pouya
AU - Gabr, Ahmed
AU - Kennedy, Kristie
AU - Salem, Riad
AU - Lewandowski, Robert J.
N1 - Funding Information:
R.S. is a consultant to Boston Scientific and Sirtex. R.J.L. is a consultant to Boston Scientific and receives a research grant from National Cancer Institute (1R01CA233878–02).
Publisher Copyright:
© 2021 Thieme Medical Publishers, Inc.. All rights reserved.
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Surgical resection has long been considered curative for patients with early-stage hepatocellular carcinoma (HCC). However, inadequate future liver remnant (FLR) renders many patients not amenable to surgery. Recently, lobar administration of yttrium-90 (Y90) radioembolization has been utilized to induce FLR hypertrophy while providing disease control, eventually facilitating resection in patients with hepatic malignancy. This has been termed radiation lobectomy (RL). The concept is evolving, with modified approaches combining RL and high-dose curative-intent radioembolization (radiation segmentectomy) to achieve tumor ablation. This article provides an overview of the concept and applications of RL, including technical considerations and outcomes in patients with hepatic malignancies.
AB - Surgical resection has long been considered curative for patients with early-stage hepatocellular carcinoma (HCC). However, inadequate future liver remnant (FLR) renders many patients not amenable to surgery. Recently, lobar administration of yttrium-90 (Y90) radioembolization has been utilized to induce FLR hypertrophy while providing disease control, eventually facilitating resection in patients with hepatic malignancy. This has been termed radiation lobectomy (RL). The concept is evolving, with modified approaches combining RL and high-dose curative-intent radioembolization (radiation segmentectomy) to achieve tumor ablation. This article provides an overview of the concept and applications of RL, including technical considerations and outcomes in patients with hepatic malignancies.
KW - future liver remnant
KW - hepatocellular carcinoma
KW - interventional radiology
KW - radiation lobectomy
KW - radioembolization
UR - http://www.scopus.com/inward/record.url?scp=85116881961&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85116881961&partnerID=8YFLogxK
U2 - 10.1055/s-0041-1735530
DO - 10.1055/s-0041-1735530
M3 - Review article
C2 - 34629708
AN - SCOPUS:85116881961
SN - 0739-9529
VL - 38
SP - 419
EP - 424
JO - Seminars in Interventional Radiology
JF - Seminars in Interventional Radiology
IS - 4
ER -