Radiation segmentectomy: A novel approach to increase safety and efficacy of radioembolization

Ahsun Riaz, Vanessa L. Gates, Bassel Atassi, Robert J. Lewandowski, Mary F. Mulcahy, Robert K. Ryu, Kent T. Sato, Talia Baker, Laura Kulik, Ramona Gupta, Michael Abecassis, Al B. Benson, Reed Omary, Laura Millender, Andrew Kennedy, Riad Salem*

*Corresponding author for this work

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Purpose: To describe a technique of segmental radioembolization for the treatment of patients with unresectable hepatocellular carcinoma (HCC). Radiation segmentectomy was defined as radioembolization of two or fewer hepatic segments. We sought to (1) calculate dose when activity is delivered segmentally assuming uniform and nonuniform distribution and, (2) determine safety and efficacy of this novel technique. Methods and Materials: A total of 84 patients with HCC who were treated with 90Y radioembolization using a segmental approach were included in this analysis. The dose delivered to the segment was calculated assuming uniform and nonuniform microsphere distribution within the treatment volume. To calculate dose assuming nonuniform distribution, a tumor hypervascularity ratio was assigned. Posttreatment response (using size and necrosis guidelines), toxicity, time to progression, and survival were determined. Results: The median treatment volume was 110 cm 3. The median radiation-naïve liver volume was 1403 cm 3. The median dose delivered to the segment(s) assuming uniform distribution was 521 Gy. Taking into account tumor hypervascularity (nonuniform distribution), the median dose delivered to the tumor and normal infused hepatic volume was 1214 Gy and 210 Gy, respectively. Response by size and necrosis guidelines was seen in 59% and 81% of patients. Grade 3/4 biochemical toxicities were observed in 8 patients (9%). Median time to progression was 13.6 months (95% confidence interval, 9.3-18.7 months); median survival was 26.9 months (95% confidence interval, 20.5-30.2 months). Conclusions: Radiation segmentectomy is a safe and efficacious method of selectively delivering high dose to the tumor with minimal exposure of normal parenchyma.

Original languageEnglish (US)
Pages (from-to)163-171
Number of pages9
JournalInternational Journal of Radiation Oncology Biology Physics
Volume79
Issue number1
DOIs
StatePublished - Jan 1 2011

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Segmental Mastectomy
safety
Radiation
Safety
dosage
radiation
tumors
Hepatocellular Carcinoma
Liver
Neoplasms
Necrosis
necrosis
Guidelines
Confidence Intervals
progressions
toxicity
Survival
confidence
cancer
Microspheres

Keywords

  • Hepatocellular carcinoma
  • Radiation segmentectomy
  • Radioembolization

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

@article{ae6d629002fa4d36bcd21067715f2709,
title = "Radiation segmentectomy: A novel approach to increase safety and efficacy of radioembolization",
abstract = "Purpose: To describe a technique of segmental radioembolization for the treatment of patients with unresectable hepatocellular carcinoma (HCC). Radiation segmentectomy was defined as radioembolization of two or fewer hepatic segments. We sought to (1) calculate dose when activity is delivered segmentally assuming uniform and nonuniform distribution and, (2) determine safety and efficacy of this novel technique. Methods and Materials: A total of 84 patients with HCC who were treated with 90Y radioembolization using a segmental approach were included in this analysis. The dose delivered to the segment was calculated assuming uniform and nonuniform microsphere distribution within the treatment volume. To calculate dose assuming nonuniform distribution, a tumor hypervascularity ratio was assigned. Posttreatment response (using size and necrosis guidelines), toxicity, time to progression, and survival were determined. Results: The median treatment volume was 110 cm 3. The median radiation-na{\"i}ve liver volume was 1403 cm 3. The median dose delivered to the segment(s) assuming uniform distribution was 521 Gy. Taking into account tumor hypervascularity (nonuniform distribution), the median dose delivered to the tumor and normal infused hepatic volume was 1214 Gy and 210 Gy, respectively. Response by size and necrosis guidelines was seen in 59{\%} and 81{\%} of patients. Grade 3/4 biochemical toxicities were observed in 8 patients (9{\%}). Median time to progression was 13.6 months (95{\%} confidence interval, 9.3-18.7 months); median survival was 26.9 months (95{\%} confidence interval, 20.5-30.2 months). Conclusions: Radiation segmentectomy is a safe and efficacious method of selectively delivering high dose to the tumor with minimal exposure of normal parenchyma.",
keywords = "Hepatocellular carcinoma, Radiation segmentectomy, Radioembolization",
author = "Ahsun Riaz and Gates, {Vanessa L.} and Bassel Atassi and Lewandowski, {Robert J.} and Mulcahy, {Mary F.} and Ryu, {Robert K.} and Sato, {Kent T.} and Talia Baker and Laura Kulik and Ramona Gupta and Michael Abecassis and Benson, {Al B.} and Reed Omary and Laura Millender and Andrew Kennedy and Riad Salem",
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Radiation segmentectomy : A novel approach to increase safety and efficacy of radioembolization. / Riaz, Ahsun; Gates, Vanessa L.; Atassi, Bassel; Lewandowski, Robert J.; Mulcahy, Mary F.; Ryu, Robert K.; Sato, Kent T.; Baker, Talia; Kulik, Laura; Gupta, Ramona; Abecassis, Michael; Benson, Al B.; Omary, Reed; Millender, Laura; Kennedy, Andrew; Salem, Riad.

In: International Journal of Radiation Oncology Biology Physics, Vol. 79, No. 1, 01.01.2011, p. 163-171.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Radiation segmentectomy

T2 - A novel approach to increase safety and efficacy of radioembolization

AU - Riaz, Ahsun

AU - Gates, Vanessa L.

AU - Atassi, Bassel

AU - Lewandowski, Robert J.

AU - Mulcahy, Mary F.

AU - Ryu, Robert K.

AU - Sato, Kent T.

AU - Baker, Talia

AU - Kulik, Laura

AU - Gupta, Ramona

AU - Abecassis, Michael

AU - Benson, Al B.

AU - Omary, Reed

AU - Millender, Laura

AU - Kennedy, Andrew

AU - Salem, Riad

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N2 - Purpose: To describe a technique of segmental radioembolization for the treatment of patients with unresectable hepatocellular carcinoma (HCC). Radiation segmentectomy was defined as radioembolization of two or fewer hepatic segments. We sought to (1) calculate dose when activity is delivered segmentally assuming uniform and nonuniform distribution and, (2) determine safety and efficacy of this novel technique. Methods and Materials: A total of 84 patients with HCC who were treated with 90Y radioembolization using a segmental approach were included in this analysis. The dose delivered to the segment was calculated assuming uniform and nonuniform microsphere distribution within the treatment volume. To calculate dose assuming nonuniform distribution, a tumor hypervascularity ratio was assigned. Posttreatment response (using size and necrosis guidelines), toxicity, time to progression, and survival were determined. Results: The median treatment volume was 110 cm 3. The median radiation-naïve liver volume was 1403 cm 3. The median dose delivered to the segment(s) assuming uniform distribution was 521 Gy. Taking into account tumor hypervascularity (nonuniform distribution), the median dose delivered to the tumor and normal infused hepatic volume was 1214 Gy and 210 Gy, respectively. Response by size and necrosis guidelines was seen in 59% and 81% of patients. Grade 3/4 biochemical toxicities were observed in 8 patients (9%). Median time to progression was 13.6 months (95% confidence interval, 9.3-18.7 months); median survival was 26.9 months (95% confidence interval, 20.5-30.2 months). Conclusions: Radiation segmentectomy is a safe and efficacious method of selectively delivering high dose to the tumor with minimal exposure of normal parenchyma.

AB - Purpose: To describe a technique of segmental radioembolization for the treatment of patients with unresectable hepatocellular carcinoma (HCC). Radiation segmentectomy was defined as radioembolization of two or fewer hepatic segments. We sought to (1) calculate dose when activity is delivered segmentally assuming uniform and nonuniform distribution and, (2) determine safety and efficacy of this novel technique. Methods and Materials: A total of 84 patients with HCC who were treated with 90Y radioembolization using a segmental approach were included in this analysis. The dose delivered to the segment was calculated assuming uniform and nonuniform microsphere distribution within the treatment volume. To calculate dose assuming nonuniform distribution, a tumor hypervascularity ratio was assigned. Posttreatment response (using size and necrosis guidelines), toxicity, time to progression, and survival were determined. Results: The median treatment volume was 110 cm 3. The median radiation-naïve liver volume was 1403 cm 3. The median dose delivered to the segment(s) assuming uniform distribution was 521 Gy. Taking into account tumor hypervascularity (nonuniform distribution), the median dose delivered to the tumor and normal infused hepatic volume was 1214 Gy and 210 Gy, respectively. Response by size and necrosis guidelines was seen in 59% and 81% of patients. Grade 3/4 biochemical toxicities were observed in 8 patients (9%). Median time to progression was 13.6 months (95% confidence interval, 9.3-18.7 months); median survival was 26.9 months (95% confidence interval, 20.5-30.2 months). Conclusions: Radiation segmentectomy is a safe and efficacious method of selectively delivering high dose to the tumor with minimal exposure of normal parenchyma.

KW - Hepatocellular carcinoma

KW - Radiation segmentectomy

KW - Radioembolization

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