Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium: Incorporating Stem Cell Hypotheses into Clinical Trials

Wendy A. Woodward*, Robert G. Bristow, Michael F. Clarke, Robert P. Coppes, Massimo Cristofanilli, Dan G. Duda, John R. Fike, Dolores Hambardzumyan, Richard P. Hill, Craig T. Jordan, Luka Milas, Frank Pajonk, Walter J. Curran, Adam P. Dicker, Yuhchyau Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

At a meeting of the Translation Research Program of the Radiation Therapy Oncology Group held in early 2008, attendees focused on updating the current state of knowledge in cancer stem cell research and discussing ways in which this knowledge can be translated into clinical use across all disease sites. This report summarizes the major topics discussed and the future directions that research should take. Major conclusions of the symposium were that the flow cytometry of multiple markers in fresh tissue would remain the standard technique of evaluating cancer-initiating cells and that surrogates need to be developed for both experimental and clinical use.

Original languageEnglish (US)
Pages (from-to)1580-1591
Number of pages12
JournalInternational Journal of Radiation Oncology Biology Physics
Volume74
Issue number5
DOIs
StatePublished - Aug 1 2009

Keywords

  • Cancer
  • Clonogens
  • Radiation therapy
  • Radiobiology
  • Stem cell

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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