Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium: Incorporating Stem Cell Hypotheses into Clinical Trials

Wendy A. Woodward; Robert G. Bristow; Michael F. Clarke; Robert P. Coppes; Massimo Cristofanilli; Dan G. Duda; John R. Fike; Dolores Hambardzumyan; Richard P. Hill; Craig T. Jordan; Luka Milas; Frank Pajonk; Walter J. Curran; Adam P. Dicker; Yuhchyau Chen

doi:10.1016/j.ijrobp.2009.03.047

Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium: Incorporating Stem Cell Hypotheses into Clinical Trials

Wendy A. Woodward^*, Robert G. Bristow, Michael F. Clarke, Robert P. Coppes, Massimo Cristofanilli, Dan G. Duda, John R. Fike, Dolores Hambardzumyan, Richard P. Hill, Craig T. Jordan, Luka Milas, Frank Pajonk, Walter J. Curran, Adam P. Dicker, Yuhchyau Chen

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

At a meeting of the Translation Research Program of the Radiation Therapy Oncology Group held in early 2008, attendees focused on updating the current state of knowledge in cancer stem cell research and discussing ways in which this knowledge can be translated into clinical use across all disease sites. This report summarizes the major topics discussed and the future directions that research should take. Major conclusions of the symposium were that the flow cytometry of multiple markers in fresh tissue would remain the standard technique of evaluating cancer-initiating cells and that surrogates need to be developed for both experimental and clinical use.

Original language	English (US)
Pages (from-to)	1580-1591
Number of pages	12
Journal	International Journal of Radiation Oncology Biology Physics
Volume	74
Issue number	5
DOIs	https://doi.org/10.1016/j.ijrobp.2009.03.047
State	Published - Aug 1 2009

Keywords

Cancer
Clonogens
Radiation therapy
Radiobiology
Stem cell

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ijrobp.2009.03.047

Cite this

Woodward, W. A., Bristow, R. G., Clarke, M. F., Coppes, R. P., Cristofanilli, M., Duda, D. G., Fike, J. R., Hambardzumyan, D., Hill, R. P., Jordan, C. T., Milas, L., Pajonk, F., Curran, W. J., Dicker, A. P., & Chen, Y. (2009). Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium: Incorporating Stem Cell Hypotheses into Clinical Trials. International Journal of Radiation Oncology Biology Physics, 74(5), 1580-1591. https://doi.org/10.1016/j.ijrobp.2009.03.047

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title = "Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium: Incorporating Stem Cell Hypotheses into Clinical Trials",

abstract = "At a meeting of the Translation Research Program of the Radiation Therapy Oncology Group held in early 2008, attendees focused on updating the current state of knowledge in cancer stem cell research and discussing ways in which this knowledge can be translated into clinical use across all disease sites. This report summarizes the major topics discussed and the future directions that research should take. Major conclusions of the symposium were that the flow cytometry of multiple markers in fresh tissue would remain the standard technique of evaluating cancer-initiating cells and that surrogates need to be developed for both experimental and clinical use.",

keywords = "Cancer, Clonogens, Radiation therapy, Radiobiology, Stem cell",

author = "Woodward, {Wendy A.} and Bristow, {Robert G.} and Clarke, {Michael F.} and Coppes, {Robert P.} and Massimo Cristofanilli and Duda, {Dan G.} and Fike, {John R.} and Dolores Hambardzumyan and Hill, {Richard P.} and Jordan, {Craig T.} and Luka Milas and Frank Pajonk and Curran, {Walter J.} and Dicker, {Adam P.} and Yuhchyau Chen",

year = "2009",

month = aug,

day = "1",

doi = "10.1016/j.ijrobp.2009.03.047",

language = "English (US)",

volume = "74",

pages = "1580--1591",

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Woodward, WA, Bristow, RG, Clarke, MF, Coppes, RP, Cristofanilli, M, Duda, DG, Fike, JR, Hambardzumyan, D, Hill, RP, Jordan, CT, Milas, L, Pajonk, F, Curran, WJ, Dicker, AP & Chen, Y 2009, 'Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium: Incorporating Stem Cell Hypotheses into Clinical Trials', International Journal of Radiation Oncology Biology Physics, vol. 74, no. 5, pp. 1580-1591. https://doi.org/10.1016/j.ijrobp.2009.03.047

Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium: Incorporating Stem Cell Hypotheses into Clinical Trials. / Woodward, Wendy A.; Bristow, Robert G.; Clarke, Michael F. et al.
In: International Journal of Radiation Oncology Biology Physics, Vol. 74, No. 5, 01.08.2009, p. 1580-1591.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium

T2 - Incorporating Stem Cell Hypotheses into Clinical Trials

AU - Woodward, Wendy A.

AU - Bristow, Robert G.

AU - Clarke, Michael F.

AU - Coppes, Robert P.

AU - Cristofanilli, Massimo

AU - Duda, Dan G.

AU - Fike, John R.

AU - Hambardzumyan, Dolores

AU - Hill, Richard P.

AU - Jordan, Craig T.

AU - Milas, Luka

AU - Pajonk, Frank

AU - Curran, Walter J.

AU - Dicker, Adam P.

AU - Chen, Yuhchyau

PY - 2009/8/1

Y1 - 2009/8/1

N2 - At a meeting of the Translation Research Program of the Radiation Therapy Oncology Group held in early 2008, attendees focused on updating the current state of knowledge in cancer stem cell research and discussing ways in which this knowledge can be translated into clinical use across all disease sites. This report summarizes the major topics discussed and the future directions that research should take. Major conclusions of the symposium were that the flow cytometry of multiple markers in fresh tissue would remain the standard technique of evaluating cancer-initiating cells and that surrogates need to be developed for both experimental and clinical use.

AB - At a meeting of the Translation Research Program of the Radiation Therapy Oncology Group held in early 2008, attendees focused on updating the current state of knowledge in cancer stem cell research and discussing ways in which this knowledge can be translated into clinical use across all disease sites. This report summarizes the major topics discussed and the future directions that research should take. Major conclusions of the symposium were that the flow cytometry of multiple markers in fresh tissue would remain the standard technique of evaluating cancer-initiating cells and that surrogates need to be developed for both experimental and clinical use.

KW - Cancer

KW - Clonogens

KW - Radiation therapy

KW - Radiobiology

KW - Stem cell

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SP - 1580

EP - 1591

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

IS - 5

ER -

Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium: Incorporating Stem Cell Hypotheses into Clinical Trials

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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