TY - JOUR
T1 - Radical-Enriched Artificial Melanin
AU - Cao, Wei
AU - Mantanona, Alex J.
AU - Mao, Haochuan
AU - McCallum, Naneki C.
AU - Jiao, Yang
AU - Battistella, Claudia
AU - Caponetti, Valeria
AU - Zang, Nanzhi
AU - Thompson, Matthew P.
AU - Montalti, Marco
AU - Stoddart, J. Fraser
AU - Wasielewski, Michael R.
AU - Rinehart, Jeffrey D.
AU - Gianneschi, Nathan C.
N1 - Funding Information:
This work was supported by a MURI grant through the Air Force Office of Scientific Research (no. FA9550-18-1-0142). EPR spectroscopy was supported by the National Science Foundation under award no. CHE-1900422 (M.R.W.). Y.J. and J.F.S. thank Northwestern University for their support to their contribution on this research project.
Publisher Copyright:
© 2020 American Chemical Society.
PY - 2020/7/14
Y1 - 2020/7/14
N2 - Melanin is a class of ubiquitous, heterogeneous, polymeric pigments. One of the most unusual features of melanin is the presence of stable persistent radicals, which has been reported to relate to ionizing radiation protection, including X-rays and gamma rays. In this work, we aimed to increase the radical content by introducing nitroxide radicals into synthetic melanin nanomaterials. Nanoparticles (NPs) were prepared by copolymerization of a stable radical modified monomer with the monomer dopamine. The radical content increased to 1 order of magnitude higher than that of the conventional melanin-like material, polydopamine. These radical NPs can enter human epidermal keratinocytes and form perinuclear caps, mimicking natural melanin synthesized by melanocytes. We demonstrated that these NPs display protective properties by scavenging reactive oxygen species, one of the most important biological effects of ionizing radiation exposure. This finding may have potential application for materials capable of mitigating side effects of clinical radiation therapy.
AB - Melanin is a class of ubiquitous, heterogeneous, polymeric pigments. One of the most unusual features of melanin is the presence of stable persistent radicals, which has been reported to relate to ionizing radiation protection, including X-rays and gamma rays. In this work, we aimed to increase the radical content by introducing nitroxide radicals into synthetic melanin nanomaterials. Nanoparticles (NPs) were prepared by copolymerization of a stable radical modified monomer with the monomer dopamine. The radical content increased to 1 order of magnitude higher than that of the conventional melanin-like material, polydopamine. These radical NPs can enter human epidermal keratinocytes and form perinuclear caps, mimicking natural melanin synthesized by melanocytes. We demonstrated that these NPs display protective properties by scavenging reactive oxygen species, one of the most important biological effects of ionizing radiation exposure. This finding may have potential application for materials capable of mitigating side effects of clinical radiation therapy.
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U2 - 10.1021/acs.chemmater.0c01573
DO - 10.1021/acs.chemmater.0c01573
M3 - Article
AN - SCOPUS:85088099974
SN - 0897-4756
VL - 32
SP - 5759
EP - 5767
JO - Chemistry of Materials
JF - Chemistry of Materials
IS - 13
ER -