Radioembolization for hepatocellular carcinoma: A review of the evidence and treatment recommendations

Bruno Sangro, Riad Salem, Andrew Kennedy*, Douglas Coldwell, Harpreet Wasan

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations


Treatment decisions for hepatocellular carcinoma involve the evaluation of multiple factors including tumor size, location, and morphology; comorbidity and/or extrahepatic disease; health status; patient preferences; and the treating physician's expertise and skill. For patients who are not candidates for transplant or resection, and for whom other therapies (radiofrequency ablation, systemic chemotherapies, transarterial embolization or chemoembolization), may have limited efficacy, an urgent need for bridging procedures, to enable surgery or ablation, or meet transplantation criteria, has led to investigations with radioembolization. A number of recent reports have supported the effectiveness of Yttrium-90 (90Y) labeled microspheres to treat intermediate and advanced disease in patients with good overall functional status and liver reserve; patients with portal vein involvement and in a limited role to treat unresectable early-stage disease. This review addresses response rates and survival benefit following radioembolization in different patient populations, in centers throughout Europe, North America, and Asia, and across the spectrum of patients presenting with various prognostic factors. By using stringent selection criteria and conservative models for calculating radiation dosage, radioembolization can be performed safely even in cirrhotic patients, without postembolization syndrome or radiation-induced liver disease, and even with multiple treatments to whole or part of the liver.

Original languageEnglish (US)
Pages (from-to)422-431
Number of pages10
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Issue number4
StatePublished - Aug 2011


  • hepatic
  • hepatocellular
  • liver
  • tumor
  • yttrium-90

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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