Radiographically normal knees with contralateral joint space narrowing display greater change in cartilage transverse relaxation time than those with normal contralateral knees: a model of early OA? – data from the Osteoarthritis Initiative (OAI)

W. Wirth; S. Maschek; F. W. Roemer; L. Sharma; G. N. Duda; F. Eckstein

doi:10.1016/j.joca.2019.06.013

Radiographically normal knees with contralateral joint space narrowing display greater change in cartilage transverse relaxation time than those with normal contralateral knees: a model of early OA? – data from the Osteoarthritis Initiative (OAI)

W. Wirth^*, S. Maschek, F. W. Roemer, L. Sharma, G. N. Duda, F. Eckstein

^*Corresponding author for this work

Medicine, Rheumatology Division

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Objective: To develop a model of early osteoarthritis, by examining whether radiographically normal knees with contralateral joint space narrowing (JSN), but without contralateral trauma history, display greater longitudinal cartilage composition change (transverse relaxation time; T2) than subjects with bilaterally normal knees. Methods: 120 radiographically normal knees (Kellgren Lawrence grade [KLG] 0) from the Osteoarthritis Initiative were studied. 60 case knees displayed definite contralateral radiographic knee osteoarthritis (KLG ≥ 2) whereas 60 reference subjects were bilaterally KLG0, and were matched 1:1 to cases based on age, sex, and BMI. All had multi-echo spin-echo MRI acquired at year (Y) 1 and 4 follow-up, with cartilage T2 being determined in superficial and deep cartilage layers across 16 femorotibial subregions. T2 across all regions was considered the primary analytic focus. Results: Of 60 KLG0 case knees (30 female, age: 65.0 ± 8.8 y, BMI: 27.6 ± 4.4 kg/m²), 21/22/13/4 displayed contralateral JSN 0/1/2/3, respectively. The longitudinal increase in the deep layer cartilage T2 between Y1 and Y4 was significantly greater (P = 0.03; Cohen's D 0.50) in the 39 KLG0 case knees with contralateral JSN (1.2 ms; 95% confidence interval [CI] [0.4, 2.0]) than in matched KLG0 reference knees (0.1 ms; 95% CI [−0.5, 0.7]). No significant differences were identified in superficial T2 change. T2 at Y1 was significantly greater in case than in reference knees, particularly in the superficial layer of the medial compartment. Conclusions: Radiographically normal knees with contralateral, non-traumatic JSN represent an applicable model of early osteoarthritis, with deep layer cartilage composition (T2) changing more rapidly than in bilaterally normal knees. Clinicaltrials.gov identification: NCT00080171.

Original language	English (US)
Pages (from-to)	1663-1668
Number of pages	6
Journal	Osteoarthritis and Cartilage
Volume	27
Issue number	11
DOIs	https://doi.org/10.1016/j.joca.2019.06.013
State	Published - Nov 2019

Funding

The cartilage transverse relaxation time (T2) analysis in this study was funded by the Bundesministerium für Bildung und Forschung (BMBF – 01EC1408D ; OVERLOAD-PREVOP). Cartilage thickness analysis in the reference sample was supported by an OAI ancillary study grant held by the Division of Rheumatology, Feinberg School of Medicine, Northwestern University (NIH/NIAMS R01 AR52918 ), and the time spent by L.S. in contributing to the study by NIH/ NIAMS P30 AR072579 and R01 AR065473 . This work was performed using publicly available data from the Osteoarthritis Initiative (OAI): The OAI (clinicaltrials.gov identifier: NCT00080171) is a public-private partnership comprised of five contracts (N01-AR-2-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-2-2261; N01-AR-2-2262) funded by the National Institutes of Health. Funding partners include Merck Research Laboratories; Novartis Pharmaceuticals Corporation, GlaxoSmithKline; and Pfizer, Inc. Private sector funding for the Consortium and OAI is managed by the FNIH.The cartilage transverse relaxation time (T2) analysis in this study was funded by the Bundesministerium f?r Bildung und Forschung (BMBF ? 01EC1408D; OVERLOAD-PREVOP). Cartilage thickness analysis in the reference sample was supported by an OAI ancillary study grant held by the Division of Rheumatology, Feinberg School of Medicine, Northwestern University (NIH/NIAMS R01 AR52918), and the time spent by L.S. in contributing to the study by NIH/NIAMS P30 AR072579 and R01 AR065473.

Keywords

Cartilage T2
Cartilage composition
Cartilage transverse relaxation time
MRI
Model of early osteoarthritis

ASJC Scopus subject areas

Rheumatology
Biomedical Engineering
Orthopedics and Sports Medicine

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Wirth, W., Maschek, S., Roemer, F. W., Sharma, L., Duda, G. N., & Eckstein, F. (2019). Radiographically normal knees with contralateral joint space narrowing display greater change in cartilage transverse relaxation time than those with normal contralateral knees: a model of early OA? – data from the Osteoarthritis Initiative (OAI). Osteoarthritis and Cartilage, 27(11), 1663-1668. https://doi.org/10.1016/j.joca.2019.06.013

Wirth, W. ; Maschek, S. ; Roemer, F. W. et al. / Radiographically normal knees with contralateral joint space narrowing display greater change in cartilage transverse relaxation time than those with normal contralateral knees : a model of early OA? – data from the Osteoarthritis Initiative (OAI). In: Osteoarthritis and Cartilage. 2019 ; Vol. 27, No. 11. pp. 1663-1668.

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title = "Radiographically normal knees with contralateral joint space narrowing display greater change in cartilage transverse relaxation time than those with normal contralateral knees: a model of early OA? – data from the Osteoarthritis Initiative (OAI)",

abstract = "Objective: To develop a model of early osteoarthritis, by examining whether radiographically normal knees with contralateral joint space narrowing (JSN), but without contralateral trauma history, display greater longitudinal cartilage composition change (transverse relaxation time; T2) than subjects with bilaterally normal knees. Methods: 120 radiographically normal knees (Kellgren Lawrence grade [KLG] 0) from the Osteoarthritis Initiative were studied. 60 case knees displayed definite contralateral radiographic knee osteoarthritis (KLG ≥ 2) whereas 60 reference subjects were bilaterally KLG0, and were matched 1:1 to cases based on age, sex, and BMI. All had multi-echo spin-echo MRI acquired at year (Y) 1 and 4 follow-up, with cartilage T2 being determined in superficial and deep cartilage layers across 16 femorotibial subregions. T2 across all regions was considered the primary analytic focus. Results: Of 60 KLG0 case knees (30 female, age: 65.0 ± 8.8 y, BMI: 27.6 ± 4.4 kg/m2), 21/22/13/4 displayed contralateral JSN 0/1/2/3, respectively. The longitudinal increase in the deep layer cartilage T2 between Y1 and Y4 was significantly greater (P = 0.03; Cohen's D 0.50) in the 39 KLG0 case knees with contralateral JSN (1.2 ms; 95% confidence interval [CI] [0.4, 2.0]) than in matched KLG0 reference knees (0.1 ms; 95% CI [−0.5, 0.7]). No significant differences were identified in superficial T2 change. T2 at Y1 was significantly greater in case than in reference knees, particularly in the superficial layer of the medial compartment. Conclusions: Radiographically normal knees with contralateral, non-traumatic JSN represent an applicable model of early osteoarthritis, with deep layer cartilage composition (T2) changing more rapidly than in bilaterally normal knees. Clinicaltrials.gov identification: NCT00080171.",

keywords = "Cartilage T2, Cartilage composition, Cartilage transverse relaxation time, MRI, Model of early osteoarthritis",

author = "W. Wirth and S. Maschek and Roemer, {F. W.} and L. Sharma and Duda, {G. N.} and F. Eckstein",

note = "Publisher Copyright: {\textcopyright} 2019 Osteoarthritis Research Society International",

year = "2019",

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doi = "10.1016/j.joca.2019.06.013",

language = "English (US)",

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Wirth, W, Maschek, S, Roemer, FW, Sharma, L, Duda, GN & Eckstein, F 2019, 'Radiographically normal knees with contralateral joint space narrowing display greater change in cartilage transverse relaxation time than those with normal contralateral knees: a model of early OA? – data from the Osteoarthritis Initiative (OAI)', Osteoarthritis and Cartilage, vol. 27, no. 11, pp. 1663-1668. https://doi.org/10.1016/j.joca.2019.06.013

Radiographically normal knees with contralateral joint space narrowing display greater change in cartilage transverse relaxation time than those with normal contralateral knees: a model of early OA? – data from the Osteoarthritis Initiative (OAI). / Wirth, W.; Maschek, S.; Roemer, F. W. et al.
In: Osteoarthritis and Cartilage, Vol. 27, No. 11, 11.2019, p. 1663-1668.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Radiographically normal knees with contralateral joint space narrowing display greater change in cartilage transverse relaxation time than those with normal contralateral knees

T2 - a model of early OA? – data from the Osteoarthritis Initiative (OAI)

AU - Wirth, W.

AU - Maschek, S.

AU - Roemer, F. W.

AU - Sharma, L.

AU - Duda, G. N.

AU - Eckstein, F.

PY - 2019/11

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N2 - Objective: To develop a model of early osteoarthritis, by examining whether radiographically normal knees with contralateral joint space narrowing (JSN), but without contralateral trauma history, display greater longitudinal cartilage composition change (transverse relaxation time; T2) than subjects with bilaterally normal knees. Methods: 120 radiographically normal knees (Kellgren Lawrence grade [KLG] 0) from the Osteoarthritis Initiative were studied. 60 case knees displayed definite contralateral radiographic knee osteoarthritis (KLG ≥ 2) whereas 60 reference subjects were bilaterally KLG0, and were matched 1:1 to cases based on age, sex, and BMI. All had multi-echo spin-echo MRI acquired at year (Y) 1 and 4 follow-up, with cartilage T2 being determined in superficial and deep cartilage layers across 16 femorotibial subregions. T2 across all regions was considered the primary analytic focus. Results: Of 60 KLG0 case knees (30 female, age: 65.0 ± 8.8 y, BMI: 27.6 ± 4.4 kg/m2), 21/22/13/4 displayed contralateral JSN 0/1/2/3, respectively. The longitudinal increase in the deep layer cartilage T2 between Y1 and Y4 was significantly greater (P = 0.03; Cohen's D 0.50) in the 39 KLG0 case knees with contralateral JSN (1.2 ms; 95% confidence interval [CI] [0.4, 2.0]) than in matched KLG0 reference knees (0.1 ms; 95% CI [−0.5, 0.7]). No significant differences were identified in superficial T2 change. T2 at Y1 was significantly greater in case than in reference knees, particularly in the superficial layer of the medial compartment. Conclusions: Radiographically normal knees with contralateral, non-traumatic JSN represent an applicable model of early osteoarthritis, with deep layer cartilage composition (T2) changing more rapidly than in bilaterally normal knees. Clinicaltrials.gov identification: NCT00080171.

AB - Objective: To develop a model of early osteoarthritis, by examining whether radiographically normal knees with contralateral joint space narrowing (JSN), but without contralateral trauma history, display greater longitudinal cartilage composition change (transverse relaxation time; T2) than subjects with bilaterally normal knees. Methods: 120 radiographically normal knees (Kellgren Lawrence grade [KLG] 0) from the Osteoarthritis Initiative were studied. 60 case knees displayed definite contralateral radiographic knee osteoarthritis (KLG ≥ 2) whereas 60 reference subjects were bilaterally KLG0, and were matched 1:1 to cases based on age, sex, and BMI. All had multi-echo spin-echo MRI acquired at year (Y) 1 and 4 follow-up, with cartilage T2 being determined in superficial and deep cartilage layers across 16 femorotibial subregions. T2 across all regions was considered the primary analytic focus. Results: Of 60 KLG0 case knees (30 female, age: 65.0 ± 8.8 y, BMI: 27.6 ± 4.4 kg/m2), 21/22/13/4 displayed contralateral JSN 0/1/2/3, respectively. The longitudinal increase in the deep layer cartilage T2 between Y1 and Y4 was significantly greater (P = 0.03; Cohen's D 0.50) in the 39 KLG0 case knees with contralateral JSN (1.2 ms; 95% confidence interval [CI] [0.4, 2.0]) than in matched KLG0 reference knees (0.1 ms; 95% CI [−0.5, 0.7]). No significant differences were identified in superficial T2 change. T2 at Y1 was significantly greater in case than in reference knees, particularly in the superficial layer of the medial compartment. Conclusions: Radiographically normal knees with contralateral, non-traumatic JSN represent an applicable model of early osteoarthritis, with deep layer cartilage composition (T2) changing more rapidly than in bilaterally normal knees. Clinicaltrials.gov identification: NCT00080171.

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KW - Cartilage composition

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KW - Model of early osteoarthritis

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Wirth W, Maschek S, Roemer FW, Sharma L, Duda GN, Eckstein F. Radiographically normal knees with contralateral joint space narrowing display greater change in cartilage transverse relaxation time than those with normal contralateral knees: a model of early OA? – data from the Osteoarthritis Initiative (OAI). Osteoarthritis and Cartilage. 2019 Nov;27(11):1663-1668. doi: 10.1016/j.joca.2019.06.013

Radiographically normal knees with contralateral joint space narrowing display greater change in cartilage transverse relaxation time than those with normal contralateral knees: a model of early OA? – data from the Osteoarthritis Initiative (OAI)

Abstract

Funding

Keywords

ASJC Scopus subject areas

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