TY - JOUR
T1 - Radiographically normal knees with contralateral joint space narrowing display greater change in cartilage transverse relaxation time than those with normal contralateral knees
T2 - a model of early OA? – data from the Osteoarthritis Initiative (OAI)
AU - Wirth, W.
AU - Maschek, S.
AU - Roemer, F. W.
AU - Sharma, L.
AU - Duda, G. N.
AU - Eckstein, F.
N1 - Funding Information:
The cartilage transverse relaxation time (T2) analysis in this study was funded by the Bundesministerium für Bildung und Forschung (BMBF – 01EC1408D ; OVERLOAD-PREVOP). Cartilage thickness analysis in the reference sample was supported by an OAI ancillary study grant held by the Division of Rheumatology, Feinberg School of Medicine, Northwestern University (NIH/NIAMS R01 AR52918 ), and the time spent by L.S. in contributing to the study by NIH/ NIAMS P30 AR072579 and R01 AR065473 .
Funding Information:
This work was performed using publicly available data from the Osteoarthritis Initiative (OAI): The OAI (clinicaltrials.gov identifier: NCT00080171) is a public-private partnership comprised of five contracts (N01-AR-2-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-2-2261; N01-AR-2-2262) funded by the National Institutes of Health. Funding partners include Merck Research Laboratories; Novartis Pharmaceuticals Corporation, GlaxoSmithKline; and Pfizer, Inc. Private sector funding for the Consortium and OAI is managed by the FNIH.The cartilage transverse relaxation time (T2) analysis in this study was funded by the Bundesministerium f?r Bildung und Forschung (BMBF ? 01EC1408D; OVERLOAD-PREVOP). Cartilage thickness analysis in the reference sample was supported by an OAI ancillary study grant held by the Division of Rheumatology, Feinberg School of Medicine, Northwestern University (NIH/NIAMS R01 AR52918), and the time spent by L.S. in contributing to the study by NIH/NIAMS P30 AR072579 and R01 AR065473.
Publisher Copyright:
© 2019 Osteoarthritis Research Society International
PY - 2019/11
Y1 - 2019/11
N2 - Objective: To develop a model of early osteoarthritis, by examining whether radiographically normal knees with contralateral joint space narrowing (JSN), but without contralateral trauma history, display greater longitudinal cartilage composition change (transverse relaxation time; T2) than subjects with bilaterally normal knees. Methods: 120 radiographically normal knees (Kellgren Lawrence grade [KLG] 0) from the Osteoarthritis Initiative were studied. 60 case knees displayed definite contralateral radiographic knee osteoarthritis (KLG ≥ 2) whereas 60 reference subjects were bilaterally KLG0, and were matched 1:1 to cases based on age, sex, and BMI. All had multi-echo spin-echo MRI acquired at year (Y) 1 and 4 follow-up, with cartilage T2 being determined in superficial and deep cartilage layers across 16 femorotibial subregions. T2 across all regions was considered the primary analytic focus. Results: Of 60 KLG0 case knees (30 female, age: 65.0 ± 8.8 y, BMI: 27.6 ± 4.4 kg/m2), 21/22/13/4 displayed contralateral JSN 0/1/2/3, respectively. The longitudinal increase in the deep layer cartilage T2 between Y1 and Y4 was significantly greater (P = 0.03; Cohen's D 0.50) in the 39 KLG0 case knees with contralateral JSN (1.2 ms; 95% confidence interval [CI] [0.4, 2.0]) than in matched KLG0 reference knees (0.1 ms; 95% CI [−0.5, 0.7]). No significant differences were identified in superficial T2 change. T2 at Y1 was significantly greater in case than in reference knees, particularly in the superficial layer of the medial compartment. Conclusions: Radiographically normal knees with contralateral, non-traumatic JSN represent an applicable model of early osteoarthritis, with deep layer cartilage composition (T2) changing more rapidly than in bilaterally normal knees. Clinicaltrials.gov identification: NCT00080171.
AB - Objective: To develop a model of early osteoarthritis, by examining whether radiographically normal knees with contralateral joint space narrowing (JSN), but without contralateral trauma history, display greater longitudinal cartilage composition change (transverse relaxation time; T2) than subjects with bilaterally normal knees. Methods: 120 radiographically normal knees (Kellgren Lawrence grade [KLG] 0) from the Osteoarthritis Initiative were studied. 60 case knees displayed definite contralateral radiographic knee osteoarthritis (KLG ≥ 2) whereas 60 reference subjects were bilaterally KLG0, and were matched 1:1 to cases based on age, sex, and BMI. All had multi-echo spin-echo MRI acquired at year (Y) 1 and 4 follow-up, with cartilage T2 being determined in superficial and deep cartilage layers across 16 femorotibial subregions. T2 across all regions was considered the primary analytic focus. Results: Of 60 KLG0 case knees (30 female, age: 65.0 ± 8.8 y, BMI: 27.6 ± 4.4 kg/m2), 21/22/13/4 displayed contralateral JSN 0/1/2/3, respectively. The longitudinal increase in the deep layer cartilage T2 between Y1 and Y4 was significantly greater (P = 0.03; Cohen's D 0.50) in the 39 KLG0 case knees with contralateral JSN (1.2 ms; 95% confidence interval [CI] [0.4, 2.0]) than in matched KLG0 reference knees (0.1 ms; 95% CI [−0.5, 0.7]). No significant differences were identified in superficial T2 change. T2 at Y1 was significantly greater in case than in reference knees, particularly in the superficial layer of the medial compartment. Conclusions: Radiographically normal knees with contralateral, non-traumatic JSN represent an applicable model of early osteoarthritis, with deep layer cartilage composition (T2) changing more rapidly than in bilaterally normal knees. Clinicaltrials.gov identification: NCT00080171.
KW - Cartilage T2
KW - Cartilage composition
KW - Cartilage transverse relaxation time
KW - MRI
KW - Model of early osteoarthritis
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U2 - 10.1016/j.joca.2019.06.013
DO - 10.1016/j.joca.2019.06.013
M3 - Article
C2 - 31301430
AN - SCOPUS:85071323372
SN - 1063-4584
VL - 27
SP - 1663
EP - 1668
JO - Osteoarthritis and Cartilage
JF - Osteoarthritis and Cartilage
IS - 11
ER -