Radioimmunoassay of pregnanediol concentrations in early morning urine specimens for assessment of luteal function in women

R. T. Chatterton, J. N. Haan, J. M. Jenco, K. L. Cheesman

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

A radioimmunoassay has been developed that employs a readily available radioligand 3H-20α-hydroxy-4-pregnen-3-one for the determination of pregnanediol glucuronide in urine. The unextracted steroid is assayed directly after dilution of urine with the use of an antiserum produced to a thyroglobulin conjugate of pregnanediol glucuronide. The assay has been validated, and the ability to assess luteal function by measurement of the concentration of pregnanediol glucuronide in early morning urine specimens has been demonstrated.

Original languageEnglish (US)
Pages (from-to)361-366
Number of pages6
JournalFertility and Sterility
Volume37
Issue number3
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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