Radiologic findings following Y90 radioembolization for primary liver malignancies

Saad M. Ibrahim, Paul Nikolaidis, Frank H. Miller, Robert J. Lewandowski, Robert K. Ryu, Kent T. Sato, Sean Senthilnathan, Ahsun Riaz, Laura Kulik, Mary F. Mulcahy, Reed A. Omary, Riad Salem*

*Corresponding author for this work

Research output: Contribution to journalReview article

52 Citations (Scopus)

Abstract

A therapy gaining rapid clinical adoption involves radioembolization with the use of Yttrium-90 (90Y) microspheres. The 20-60 μm-sized microspheres are injected trans-arterially and flow to hepatic tumors given their preferential blood supply from the hepatic artery. Once they lodge in the arterioles, they impart a very intense local radiotherapeutic effect. Given the combined radiation and embolic effect, the imaging findings imparted by this mode of action differ significantly from other treatments. This work represents a comprehensive review of the imaging findings following radioembolization in patients with primary liver tumors. The report discusses imaging response, benign secondary effects, and complications. This should help educate the radiologist on imaging findings that should be expected following radioembolization and therefore aid in the proper image interpretation.

Original languageEnglish (US)
Pages (from-to)566-581
Number of pages16
JournalAbdominal Imaging
Volume34
Issue number5
DOIs
StatePublished - Sep 1 2009

Fingerprint

Microspheres
Yttrium
Liver
Hepatic Artery
Radiation Effects
Arterioles
Neoplasms
Therapeutics
Radiologists

Keywords

  • Internal radiation
  • Radioembolization
  • SIR-Spheres
  • Selective
  • TheraSphere
  • Yttrium 90

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology
  • Urology

Cite this

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title = "Radiologic findings following Y90 radioembolization for primary liver malignancies",
abstract = "A therapy gaining rapid clinical adoption involves radioembolization with the use of Yttrium-90 (90Y) microspheres. The 20-60 μm-sized microspheres are injected trans-arterially and flow to hepatic tumors given their preferential blood supply from the hepatic artery. Once they lodge in the arterioles, they impart a very intense local radiotherapeutic effect. Given the combined radiation and embolic effect, the imaging findings imparted by this mode of action differ significantly from other treatments. This work represents a comprehensive review of the imaging findings following radioembolization in patients with primary liver tumors. The report discusses imaging response, benign secondary effects, and complications. This should help educate the radiologist on imaging findings that should be expected following radioembolization and therefore aid in the proper image interpretation.",
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Radiologic findings following Y90 radioembolization for primary liver malignancies. / Ibrahim, Saad M.; Nikolaidis, Paul; Miller, Frank H.; Lewandowski, Robert J.; Ryu, Robert K.; Sato, Kent T.; Senthilnathan, Sean; Riaz, Ahsun; Kulik, Laura; Mulcahy, Mary F.; Omary, Reed A.; Salem, Riad.

In: Abdominal Imaging, Vol. 34, No. 5, 01.09.2009, p. 566-581.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Radiologic findings following Y90 radioembolization for primary liver malignancies

AU - Ibrahim, Saad M.

AU - Nikolaidis, Paul

AU - Miller, Frank H.

AU - Lewandowski, Robert J.

AU - Ryu, Robert K.

AU - Sato, Kent T.

AU - Senthilnathan, Sean

AU - Riaz, Ahsun

AU - Kulik, Laura

AU - Mulcahy, Mary F.

AU - Omary, Reed A.

AU - Salem, Riad

PY - 2009/9/1

Y1 - 2009/9/1

N2 - A therapy gaining rapid clinical adoption involves radioembolization with the use of Yttrium-90 (90Y) microspheres. The 20-60 μm-sized microspheres are injected trans-arterially and flow to hepatic tumors given their preferential blood supply from the hepatic artery. Once they lodge in the arterioles, they impart a very intense local radiotherapeutic effect. Given the combined radiation and embolic effect, the imaging findings imparted by this mode of action differ significantly from other treatments. This work represents a comprehensive review of the imaging findings following radioembolization in patients with primary liver tumors. The report discusses imaging response, benign secondary effects, and complications. This should help educate the radiologist on imaging findings that should be expected following radioembolization and therefore aid in the proper image interpretation.

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KW - SIR-Spheres

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