Radiomic phenotypes distinguish atypical teratoid/rhabdoid tumors from medulloblastoma

M. Zhang, S. W. Wong, S. Lummus, M. Han, A. Radmanesh, S. S. Ahmadian, L. M. Prolo, H. Lai, A. Eghbal, O. Oztekin, S. H. Cheshier, P. G. Fisher, C. Y. Ho, H. Vogel, N. A. Vitanza, R. M. Lober, G. A. Grant, A. Jaju, K. W. Yeom*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

BACKGROUND AND PURPOSE: Atypical teratoid/rhabdoid tumors and medulloblastomas have similar imaging and histologic features but distinctly different outcomes. We hypothesized that they could be distinguished by MR imaging-based radiomic phenotypes. MATERIALS AND METHODS: We retrospectively assembled T2-weighted and gadolinium-enhanced T1-weighted images of 48 posterior fossa atypical teratoid/rhabdoid tumors and 96 match-paired medulloblastomas from 7 institutions. Using a holdout test set, we measured the performance of 6 candidate classifier models using 6 imaging features derived by sparse regression of 900 T2WI and 900 T1WI Imaging Biomarker Standardization Initiative-based radiomics features. RESULTS: From the originally extracted 1800 total Imaging Biomarker Standardization Initiative-based features, sparse regression consistently reduced the feature set to 1 from T1WI and 5 from T2WI. Among classifier models, logistic regression performed with the highest AUC of 0.86, with sensitivity, specificity, accuracy, and F1 scores of 0.80, 0.82, 0.81, and 0.85, respectively. The top 3 important Imaging Biomarker Standardization Initiative features, by decreasing order of relative contribution, included voxel intensity at the 90th percentile, inverse difference moment normalized, and kurtosis-all from T2WI. CONCLUSIONS: Six quantitative signatures of image intensity, texture, and morphology distinguish atypical teratoid/rhabdoid tumors from medulloblastomas with high prediction performance across different machine learning strategies. Use of this technique for preoperative diagnosis of atypical teratoid/rhabdoid tumors could significantly inform therapeutic strategies and patient care discussions.

Original languageEnglish (US)
Pages (from-to)1702-1708
Number of pages7
JournalAmerican Journal of Neuroradiology
Volume42
Issue number9
DOIs
StatePublished - Sep 1 2021

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Radiomic phenotypes distinguish atypical teratoid/rhabdoid tumors from medulloblastoma'. Together they form a unique fingerprint.

Cite this