Radiomics-Based Image Phenotyping of Kidney Apparent Diffusion Coefficient Maps: Preliminary Feasibility & Efficacy

Lu Ping Li*, Alexander S. Leidner, Emily Wilt, Artem Mikheev, Henry Rusinek, Stuart M. Sprague, Orly F. Kohn, Anand Srivastava, Pottumarthi V. Prasad

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Given the central role of interstitial fibrosis in disease progression in chronic kidney disease (CKD), a role for diffusion-weighted MRI has been pursued. We evaluated the feasibility and preliminary efficacy of using radiomic features to phenotype apparent diffusion coefficient (ADC) maps and hence to the clinical classification(s) of the participants. The study involved 40 individuals (10 healthy and 30 with CKD (eGFR < 60 mL/min/1.73 m2)). Machine learning methods, such as hierarchical clustering and logistic regression, were used. Clustering resulted in the identification of two clusters, one including all individuals with CKD (n = 17), while the second one included all the healthy volunteers (n = 10) and the remaining individuals with CKD (n = 13), resulting in 100% specificity. Logistic regression identified five radiomic features to classify participants as with CKD vs. healthy volunteers, with a sensitivity and specificity of 93% and 70%, respectively, and an AUC of 0.95. Similarly, four radiomic features were able to classify participants as rapid vs. non-rapid CKD progressors among the 30 individuals with CKD, with a sensitivity and specificity of 71% and 43%, respectively, and an AUC of 0.75. These promising preliminary data should support future studies with larger numbers of participants with varied disease severity and etiologies to improve performance.

Original languageEnglish (US)
Article number1972
JournalJournal of Clinical Medicine
Issue number7
StatePublished - Apr 1 2022


  • ADC
  • CKD
  • MRI
  • diffusion-weighted imaging
  • kidney
  • radiomic

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Radiomics-Based Image Phenotyping of Kidney Apparent Diffusion Coefficient Maps: Preliminary Feasibility & Efficacy'. Together they form a unique fingerprint.

Cite this