Radiotherapy and Glioma Stem Cells: Searching for Chinks in Cellular Armor

Seamus P. Caragher, Sean Sachdev, Atique U. Ahmed*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Purpose of Review: Radiation became a pillar of oncologic treatment in the last century and provided a powerful and effective locoregional treatment of solid malignancies. After achieving some of the first cures in lymphomas and skin cancers, it assumed a key role in the curative treatment of epithelioid malignancies. Despite success across a variety of histologic types, glioblastoma (GBM), the most common primary brain tumor afflicting adults, remains ultimately resistant to current radiation strategies. While GBMs demonstrate an initial response, recurrence is essentially universal and fatal and typically reoccur in the areas that received the most intense radiation. Recent Findings: Glioma stem cells (GSCs), a subpopulation of tumor cells with expression profiles similar to neural stem cells and marked self-renewal capacities, have been shown to drive tumor recurrence and preclude curative radiotherapy. Recent research has shown that these cells have enhanced DNA repair capacity and elevated resistance to cytotoxic ion fluxes and escape multimodality therapies. Summary: We will analyze the current understanding of GSCs and radiation by highlighting key discoveries probing their ability to withstand radiotherapy. We then speculate on novel mechanisms by which GSC can be made sensitive to or specifically targeted by radiation therapy.

Original languageEnglish (US)
Pages (from-to)348-357
Number of pages10
JournalCurrent Stem Cell Reports
Volume3
Issue number4
DOIs
StatePublished - Dec 1 2017

Keywords

  • Cancer stem cells
  • Glioblastoma multiforme
  • Radiation oncology
  • Translational oncology

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Developmental Biology
  • Cell Biology

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