Raman Dye-Labeled Nanoparticle Probes for Proteins

Y. Charles Cao; Rongchao Jin; Jwa Min Nam; C. Shad Thaxton; Chad A. Mirkin

doi:10.1021/ja0366235

Raman Dye-Labeled Nanoparticle Probes for Proteins

Y. Charles Cao, Rongchao Jin, Jwa Min Nam, C. Shad Thaxton, Chad A. Mirkin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

404 Scopus citations

Abstract

In this paper, we demonstrate how one can chemically design Raman dye-functionalized nanoparticle probes with specific protein-binding affinities and use these probes, coupled with surface-enhanced Raman scattering (SERS) spectroscopy, to perform multiplexed screening of protein?small molecule interactions and protein?protein interactions in a protein microarray format.

Original language	English (US)
Pages (from-to)	14676-14677
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	125
Issue number	48
DOIs	https://doi.org/10.1021/ja0366235
State	Published - Dec 3 2003

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja0366235

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title = "Raman Dye-Labeled Nanoparticle Probes for Proteins",

abstract = "In this paper, we demonstrate how one can chemically design Raman dye-functionalized nanoparticle probes with specific protein-binding affinities and use these probes, coupled with surface-enhanced Raman scattering (SERS) spectroscopy, to perform multiplexed screening of protein?small molecule interactions and protein?protein interactions in a protein microarray format.",

author = "Cao, {Y. Charles} and Rongchao Jin and Nam, {Jwa Min} and Thaxton, {C. Shad} and Mirkin, {Chad A.}",

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AU - Cao, Y. Charles

AU - Jin, Rongchao

AU - Nam, Jwa Min

AU - Thaxton, C. Shad

AU - Mirkin, Chad A.

PY - 2003/12/3

Y1 - 2003/12/3

N2 - In this paper, we demonstrate how one can chemically design Raman dye-functionalized nanoparticle probes with specific protein-binding affinities and use these probes, coupled with surface-enhanced Raman scattering (SERS) spectroscopy, to perform multiplexed screening of protein?small molecule interactions and protein?protein interactions in a protein microarray format.

AB - In this paper, we demonstrate how one can chemically design Raman dye-functionalized nanoparticle probes with specific protein-binding affinities and use these probes, coupled with surface-enhanced Raman scattering (SERS) spectroscopy, to perform multiplexed screening of protein?small molecule interactions and protein?protein interactions in a protein microarray format.

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JO - Journal of the American Chemical Society

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Raman Dye-Labeled Nanoparticle Probes for Proteins

Abstract

ASJC Scopus subject areas

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