Raman Dye-Labeled Nanoparticle Probes for Proteins

Y. Charles Cao, Rongchao Jin, Jwa Min Nam, C. Shad Thaxton, Chad A. Mirkin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

402 Scopus citations


In this paper, we demonstrate how one can chemically design Raman dye-functionalized nanoparticle probes with specific protein-binding affinities and use these probes, coupled with surface-enhanced Raman scattering (SERS) spectroscopy, to perform multiplexed screening of protein?small molecule interactions and protein?protein interactions in a protein microarray format.

Original languageEnglish (US)
Pages (from-to)14676-14677
Number of pages2
JournalJournal of the American Chemical Society
Issue number48
StatePublished - Dec 3 2003

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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