Random length assortment of human and mouse T cell receptor for antigen α and β chain CDR3

George Johnson, Tai T. Wu*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

In view of the recently determined three-dimensional structures of complexes formed by the T cell receptor for antigen (TCR), the processed peptide and the MHC class I molecule, it is expected that the combined configuration formed by the third complementarity determining regions (CDR3) of TCR α and β chains will be very restricted in size and shape due to the limited length variations of the processed peptides. Thus, the combined TCR α and β chain CDR3 lengths should have a fairly narrow distribution. This feature can be due to the selective association of long α chain CDR3 with short β chain CDR3 and vice versa or due to random assortment of α and β chain CDR3 of even narrower length distribution. Based on existing translated amino acid sequence data, it has been found that the latter mechanism is responsible.

Original languageEnglish (US)
Pages (from-to)391-394
Number of pages4
JournalImmunology and Cell Biology
Volume77
Issue number5
DOIs
StatePublished - 1999

Keywords

  • Random assortment
  • T cell receptor for antigen
  • Third complementarity determining region
  • α chain
  • β chain

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

Fingerprint Dive into the research topics of 'Random length assortment of human and mouse T cell receptor for antigen α and β chain CDR3'. Together they form a unique fingerprint.

  • Cite this