Randomised trial of intradermal Mycobacterium vaccae or intradermal hepatitis B immunisation in children with HIV infection

Daniel Johnson; Richard D. Waddell; Steven I. Pelton; Anna S. Jaeger; John F. Modlin; Ram Yogev; Paul Morin; Robert D. Arbeit; C. Fordham Von Reyn

doi:10.1016/S0264-410X(99)00055-9

Randomised trial of intradermal Mycobacterium vaccae or intradermal hepatitis B immunisation in children with HIV infection

Daniel Johnson, Richard D. Waddell, Steven I. Pelton, Anna S. Jaeger, John F. Modlin, Ram Yogev, Paul Morin, Robert D. Arbeit, C. Fordham Von Reyn

Pediatrics

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

This study assessed the safety of inactivated Myobacterium vaccae as a candidate vaccine to prevent disseminated mycobacterial disease in children with HIV infection 35 children ages 1-8 with CD4 counts ≥300/mm³ in New Hampshire, Boston and Chicago were randomised in a 2:1 schedule to receive a 3-dose series of intradermal M. vaccae vaccine (MV) or hepatitis B vaccine (HBV) at 2-month intervals. Immunisation was safe and well tolerated; 2-day median vaccine site induration was 5 mm in MV recipients and 0 mm in HBV recipients (p<0.001). There were no significantly different changes in viral load or CD4 count between the two vaccine groups. No PPD skin test conversion occurred after immunisation. MV is safe and well tolerated and deserves further evaluation as vaccine to prevent mycobacterial disease in HIV- infected children.

Original language	English (US)
Pages (from-to)	2583-2587
Number of pages	5
Journal	Vaccine
Volume	17
Issue number	20-21
DOIs	https://doi.org/10.1016/S0264-410X(99)00055-9
State	Published - Jun 4 1999

Keywords

HIV
Immunisation
Myobacteria

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
General Immunology and Microbiology
Infectious Diseases
Molecular Medicine
General Veterinary

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0264-410X(99)00055-9

Cite this

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title = "Randomised trial of intradermal Mycobacterium vaccae or intradermal hepatitis B immunisation in children with HIV infection",

abstract = "This study assessed the safety of inactivated Myobacterium vaccae as a candidate vaccine to prevent disseminated mycobacterial disease in children with HIV infection 35 children ages 1-8 with CD4 counts ≥300/mm3 in New Hampshire, Boston and Chicago were randomised in a 2:1 schedule to receive a 3-dose series of intradermal M. vaccae vaccine (MV) or hepatitis B vaccine (HBV) at 2-month intervals. Immunisation was safe and well tolerated; 2-day median vaccine site induration was 5 mm in MV recipients and 0 mm in HBV recipients (p<0.001). There were no significantly different changes in viral load or CD4 count between the two vaccine groups. No PPD skin test conversion occurred after immunisation. MV is safe and well tolerated and deserves further evaluation as vaccine to prevent mycobacterial disease in HIV- infected children.",

keywords = "HIV, Immunisation, Myobacteria",

author = "Daniel Johnson and Waddell, {Richard D.} and Pelton, {Steven I.} and Jaeger, {Anna S.} and Modlin, {John F.} and Ram Yogev and Paul Morin and Arbeit, {Robert D.} and {Fordham Von Reyn}, C.",

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AU - Johnson, Daniel

AU - Waddell, Richard D.

AU - Pelton, Steven I.

AU - Jaeger, Anna S.

AU - Modlin, John F.

AU - Yogev, Ram

AU - Morin, Paul

AU - Arbeit, Robert D.

AU - Fordham Von Reyn, C.

PY - 1999/6/4

Y1 - 1999/6/4

N2 - This study assessed the safety of inactivated Myobacterium vaccae as a candidate vaccine to prevent disseminated mycobacterial disease in children with HIV infection 35 children ages 1-8 with CD4 counts ≥300/mm3 in New Hampshire, Boston and Chicago were randomised in a 2:1 schedule to receive a 3-dose series of intradermal M. vaccae vaccine (MV) or hepatitis B vaccine (HBV) at 2-month intervals. Immunisation was safe and well tolerated; 2-day median vaccine site induration was 5 mm in MV recipients and 0 mm in HBV recipients (p<0.001). There were no significantly different changes in viral load or CD4 count between the two vaccine groups. No PPD skin test conversion occurred after immunisation. MV is safe and well tolerated and deserves further evaluation as vaccine to prevent mycobacterial disease in HIV- infected children.

AB - This study assessed the safety of inactivated Myobacterium vaccae as a candidate vaccine to prevent disseminated mycobacterial disease in children with HIV infection 35 children ages 1-8 with CD4 counts ≥300/mm3 in New Hampshire, Boston and Chicago were randomised in a 2:1 schedule to receive a 3-dose series of intradermal M. vaccae vaccine (MV) or hepatitis B vaccine (HBV) at 2-month intervals. Immunisation was safe and well tolerated; 2-day median vaccine site induration was 5 mm in MV recipients and 0 mm in HBV recipients (p<0.001). There were no significantly different changes in viral load or CD4 count between the two vaccine groups. No PPD skin test conversion occurred after immunisation. MV is safe and well tolerated and deserves further evaluation as vaccine to prevent mycobacterial disease in HIV- infected children.

KW - HIV

KW - Immunisation

KW - Myobacteria

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DO - 10.1016/S0264-410X(99)00055-9

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SN - 0264-410X

VL - 17

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JO - Vaccine

JF - Vaccine

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ER -

Randomised trial of intradermal Mycobacterium vaccae or intradermal hepatitis B immunisation in children with HIV infection

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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