Randomized comparison of ganciclovir plus intravenous immune globulin (IVIG) with IVIG alone for prevention of primary cytomegalovirus disease in children receiving liver transplants

Susan M. King*, Riccardo Superina, Walter Andrews, Drew J. Winston, Steven Dunn, Ronald W. Busuttil, Paul Colombani, Khazal Paradis

*Corresponding author for this work

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

A randomized placebo-controlled trial was conducted to determine the benefit of ganciclovir (5 mg/[kg·d]) for 30 days in addition to intravenous immune globulin (IVIG) for 16 weeks for prevention of primary cytomegalovirus (CMV) disease in children receiving liver transplants. Patients were monitored for 6 months after transplantation. The two groups of patients (recipients of 29 ganciclovir plus IVIG and 27 recipients of IVIG alone) were similar in terms of age, sex, and underlying disease. The incidence of CMV disease among the ganciclovir pins IVIG recipients and the IVIG alone recipients was 17% and 26%, respectively, and the time to disease in these recipients was 46 days and 32 days, respectively. There was no difference between groups in terms of survival; episodes of rejection, bacteremia, or fungemia; use of immunosuppressive agents; and incidence of leukopenia or thrombocytopenia. These results suggest that a 4-week course of ganciclovir with IVIG is not more effective than IVIG alone for prevention of primary CMV disease. Since short-term prophylaxis with ganciclovir may delay the onset of CMV disease, further studies with a longer course of ganciclovir prophylaxis are warranted.

Original languageEnglish (US)
Pages (from-to)1173-1179
Number of pages7
JournalClinical Infectious Diseases
Volume25
Issue number5
DOIs
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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